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Men with early balding showed higher levels of certain genes linked to hair loss and possibly prostate cancer.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Reduced androgens linked to kinky hair disorder and hair loss; 5a-reductase inhibitors may help.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Testosterone and dihydrotestosterone play a role in women's health issues like excess hair and baldness, and treatments blocking these hormones may help.

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

Male pattern baldness involves hormone-related hair thinning, shorter hair, and inflammation.

Plant-based treatments can effectively and safely treat hair loss.

Finasteride doesn't affect ovulation in normal women.

Finasteride, a drug used for certain conditions, can cause serious side effects like sexual dysfunction, suicidal thoughts, and increased diabetes risk, and there's a need for more awareness and research about these effects.

Asiasari radix extract promotes hair growth and increases protein synthesis and cell proliferation.

Finasteride changes antioxidant enzyme expression, possibly affecting sperm protection in rats.

Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.

Dutasteride more effective for hair growth, but has more side effects than finasteride.

Finasteride effectively reduces hair growth in women with idiopathic hirsutism, but requires careful contraception during treatment.

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

Researchers found new potential but less potent rat enzyme inhibitors using a 3D model.

Finasteride affects prostate weights and pituitary activity differently with age.