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This study discusses the rise of commercial direct-to-consumer stem cell therapies, highlighting how they are marketed as biomedical 'lifestyle' products that blend science, medicine, and consumer culture, despite ongoing safety and efficacy concerns.

In this study, treatment with autologous follicular stem cells improved hair conditions in 57% of patients with androgenic and telogen effluvium alopecia, as confirmed by phototrichograms, indicating its potential effectiveness for non-scarring alopecia.

This study investigated the secretome of adipose mesenchymal stem cells and fibroblasts used in skin care products, finding 16 therapeutic pathways involving numerous signaling mechanisms, which may offer skin benefits through anti-inflammatory and regenerative effects.

This review highlights the promising role of stem cell therapy in treating resistant diseases, while also addressing the challenges in production and clinical application, emphasizing the need for standardized manufacturing and quality assurance to enhance efficacy and safety in clinical translational research.

This study reported that bio-pulsed avian-derived mesenchymal stem cell extracellular vesicles significantly improved cell proliferation, wound healing, and gene expression in human skin fibroblasts and hair follicle cells.

This study found that the natural product Shi-Bi-Man significantly promoted hair regeneration in cynomolgus monkeys, increasing hair follicle number and activation by boosting specific protein markers and interactions in Laminin-related pathways.

This study found that the addition of SPACE peptide significantly enhanced the penetration of amniotic membrane stem cell metabolites in mice, with only very mild irritation observed.

This commentary explores the marketing of unproven and unlicensed adipose-derived stem cell treatments in US clinics, highlighting concerns about patient safety and regulatory challenges.

This study explored how Australian patients and their carers perceived autologous stem cell interventions, highlighting factors like illness experience and unrealistic expectations that influenced their decision-making in an unregulated market.

This review discusses advancements in stem cell therapy for cutaneous radiation syndrome, highlighting the potential of various stem cell sources to improve wound healing and reduce symptoms, but reports no new clinical results.

This study suggests that canonical BMP signaling, particularly involving Smad1 and Smad5, plays a critical role in hair follicle stem cell regulation and hair morphogenesis, with distinct roles from pSmad8.

This systematic review synthesizes evidence from the past 20 years to highlight the potential of exosome-based therapies from stem cells and plants in improving cutaneous repair, skin aging, and challenging dermatological conditions through mechanisms like immunomodulation and collagen remodeling.

This review found that image-guided techniques in regenerative aesthetic procedures may enhance accuracy and patient outcomes compared to traditional methods, but more high-quality randomized trials are needed to establish standardized protocols.

New treatments using stem cells and other methods show promise for promoting hair growth in androgenetic alopecia.

This study found that disrupted cholesterol homeostasis impairs hair regrowth in individuals with primary cicatricial alopecia by damaging hair follicle stem cells, highlighting the importance of cholesterol in maintaining stem cell function and hair follicle integrity.

This study found that the Stem Cell Educator therapy improved hair regrowth and quality of life in patients with severe alopecia areata by restoring immune balance and protecting hair follicles from autoimmune damage.

The researchers reported that thymosin beta 4 promotes hair growth in various rat and mice models by influencing follicle stem cell growth, migration, and differentiation.

This study reports that mesenchymal stem cell-conditioned medium promoted dermal cell migration and proliferation, enhancing wound healing but not direct hair growth, in vitro and in adult mouse models.

This study highlights the potential of stem cell-derived extracellular vesicles to treat UV-induced skin damage by modulating key signaling pathways, though challenges like EV composition variability and skin barrier penetration remain, underscoring the need for further research into optimized delivery methods for effective therapies.

This review discusses current knowledge of keratinocyte stem cell dynamics, including their regenerative roles and potential applications beyond wound healing, but presents no new clinical findings.

This review highlights the need for optimizing mesenchymal stromal/stem cell therapy through tailored in vitro strategies to unlock their full potential for treating specific diseases.

This study found that glycolytic metabolism and lactate production are crucial for hair follicle stem cell activation, and manipulating these processes can stimulate the hair cycle.

This study found that early mitochondrial reprogramming, specifically through fatty acid oxidation fueling oxidative phosphorylation, is crucial for initiating differentiation in epidermal stem cells, highlighting a potential therapeutic target for differentiation defects in skin disorders.

This review discusses current advancements in mesenchymal stem cell-based therapies for skin repair and rejuvenation, focusing on therapeutic strategies, particularly highlighting the potential of neonatal and placenta-derived MSCs, and reports no new clinical results.

In this study, exosome-like nanoparticles derived from rose stem cell culture were found to enhance skin quality by increasing collagen production, reducing melanin and inflammation, and promoting cell migration in vitro, suggesting potential aesthetic applications.

This review discusses advancements in plant cell culture technology for producing potent natural cosmetic ingredients and reports no new experimental results.

This study reviews the regulatory mechanisms and molecular processes governing stem cell activity in hair follicles, highlighting their roles in hair regeneration and potential implications for treating hair and skin disorders.

This study found that adipose-derived stem cell extracellular vesicles reduced wrinkles and promoted cell proliferation in UVB-induced photoaging in mice by decreasing oxidative stress and inflammation.

This study found that transient non-lethal levels of endogenous ROS in cultured human hair follicles promoted entry into the growth phase by activating the hair follicle stem cell niche.

This study suggests that allergens like linalool found in personal care products may contribute to the pathobiology of frontal fibrosing alopecia by affecting immune responses and stem cell function in hair follicles.