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Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

Stem cell niches support, regulate, and coordinate stem cell functions.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Chemotherapy often causes temporary hair loss, which is distressing and needs better treatment and support.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Targeted cancer therapies often cause skin reactions, so dermatologists must manage these effects.

A certain smell receptor in hair follicles can affect hair growth when activated by a synthetic sandalwood scent.

Drosha and Dicer are essential for hair follicle health and preventing DNA damage in skin cells.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

The document concludes that there are no effective clinical treatments for hearing loss due to hair cell damage, but research is ongoing.

Scientists successfully created and transplanted bioengineered hair follicles that function like natural ones, suggesting a new treatment for hair loss.

Finasteride helps reduce heart issues and improves heart function.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.

Ginseng and its compounds may help hair growth and prevent hair loss, but more human trials are needed to confirm this.

RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.

Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.

Thyrotropin-Releasing Hormone helps heal wounds in frog and human skin.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Fat cells are important for tissue repair and stem cell support in various body parts.

Blocking JAK/STAT pathways can help treat hair loss from alopecia areata.

Hormones during pregnancy and lactation keep skin stem cells inactive, preventing hair growth.

Blocking the prolactin receptor might help treat various diseases, but more research is needed.

Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.

Puerariae Flos extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.