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The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Removing the ATR gene in adult mice causes rapid aging and stem cell loss.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.

Animals that change color with the seasons mainly do so in response to daylight changes, but climate change is causing camouflage problems that may require evolutionary changes.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Male pattern hair loss is genetic and influenced by hormones, with treatments like minoxidil and surgery available.

Mutant CDP/Cux protein causes hair defects and reduced male fertility in mice.

Mutant mice help researchers understand hair growth and related genetic factors.

Maintaining DNA health in stem cells is key to preventing aging and tissue breakdown.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Dutasteride effectively treats enlarged prostate, reduces prostate cancer risk, and promotes hair regrowth with few side effects.

Group a wide range of chemicals, not just phthalates, for assessing risks to male reproductive health.

Hormones during pregnancy and lactation keep skin stem cells inactive, preventing hair growth.

A male with aromatase deficiency improved bone health with estradiol treatment.

Antiandrogens are effective for conditions like prostate cancer and skin issues, but more research is needed to confirm their benefits and minimize side effects.

Finasteride and dutasteride effectively treat hair loss in men and women, but may cause side effects like low libido and depression.

Safflower has been used in traditional medicine for centuries and shows promise in treating heart, brain, and inflammatory conditions, but more research is needed to ensure its safety.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

Cross-sex hormone therapy is important for managing gender dysphoria and requires careful monitoring and healthcare provider education.

Hydroxychloroquine showed some potential, but overall, the three drugs had limited success in treating lupus in dogs.

The genes OVOL1 and OVOL2 are important for hair growth and may be involved in a type of skin tumor.

The document concludes that oral finasteride and topical minoxidil are effective for genetic hair loss, while other treatments for different types of hair loss show promise but need more research.