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This study found that inhibiting the enzyme 5α-reductase with finasteride counteracted stress-induced prepulse inhibition deficits in socially isolated rats by altering neuroactive steroid concentrations in the brain.

In this study, finasteride reduced the severity of dopaminergic behavior manifestations in rats without causing extrapyramidal side effects, unlike other antidopaminergic agents.

This study suggests that finasteride may inhibit the enzyme phenylethanolamine N-methyltransferase, which could contribute to its sexual and psychological side effects.

This study found that duloxetine and escitalopram exhibited broad-spectrum antimicrobial activity, while buspirone had selective effects, and finasteride disrupted yeast virulence traits, suggesting these drugs could be repurposed as antimicrobial therapies.

This review discusses post-SSRI sexual dysfunction and post-finasteride syndrome, highlighting unknowns about their true incidence and underlying causes, and reports no new clinical results.

This study found that psychiatric adverse drug reactions were more frequently reported with finasteride than with dutasteride, but it remains unclear if there is a causal relationship.

This study found that antidepressants may affect loving relationships differently by gender, with women on TCAs experiencing more sexual side effects and men on SSRIs reporting reduced feelings of love and attachment.

In this animal study, the researchers found that administering anionic lipid nanoemulsions called squarticles increased survival rates and mitigated the adverse effects of amitriptyline overdose in rats.

This review summarizes the association between 5-alpha reductase inhibitors and depression, discussing potential mechanisms such as neuroactive steroid alterations and neuroinflammation, but reports no new clinical results.

This study found that acute sleep deprivation enhanced 5α-reductase expression and activity in the rat prefrontal cortex, and finasteride treatment reduced associated psychosis- and mania-like behaviors.

This report describes the enhancement of the French SNIIRAM/SNDS healthcare database through external data linkages, highlighting its potential use in medical research despite complexities in the integration process.

This paper describes the development of diagnostic criteria for several enduring sexual dysfunction conditions following the use of certain medications, highlighting common sexual and non-sexual symptoms.

In this study, paroxetine's antihyperalgesic effect in a rat model of neuropathic pain was shown to be mediated by increased levels of the neurosteroid allopregnanolone in the spine.

In this study, naringenin and its methylated derivatives reduced depression-like behaviors and inflammation markers in mice exposed to finasteride, suggesting their potential as effective and safe anti-depressive agents.

This review discusses the potential role of steroid 5α-reductase inhibitors in treating neuropsychiatric disorders related to dopaminergic hyperreactivity but reports no new clinical results.

This study found that bupropion SR may improve symptoms in female trichotillomania patients who did not respond to SSRIs, with benefits maintained through a 16-month follow-up.

This meta-analysis reports that 5-alpha-reductase inhibitors are associated with a 31% increased risk of depression, with varying outcomes depending on the comparator group, highlighting significant heterogeneity across studies.

This study found that Sonirid Duo, a combination of tamsulosin and finasteride, significantly improved symptoms and quality of life in patients with BPH over 12 months.

This review examines the use of monoaminergic antidepressants for inflammatory skin disorders and reports they may reduce dermatological symptoms, suggesting a potential role beyond treating psychiatric conditions.

This animal study found that intravenous administration of anionic squarticles, a lipid nanoemulsion, increased survival rates in rats with amitriptyline overdose by mitigating adverse effects and restoring normal blood pressure, highlighting its potential as a detoxifying antidote.