Repurposing Finasteride And Serotonin Reuptake Inhibitors As Novel Antimicrobials: A Dual-Action Approach To Target Bacterial And Fungal Pathogens

This study investigates the antimicrobial potential of repurposing finasteride and serotonin reuptake inhibitors (duloxetine, buspirone, and escitalopram) against bacterial and fungal pathogens. Duloxetine and escitalopram showed significant antifungal activity, with escitalopram also demonstrating antibacterial effects, particularly against Gram-negative bacteria. Finasteride exhibited strong antibacterial activity against Gram-negative bacteria but no antifungal effects. These drugs impaired microbial virulence factors such as biofilm formation and filamentation, suggesting a complementary approach to existing treatments. The study emphasizes the need for further research into their effects on the human microbiome, potential synergistic effects with standard antimicrobials, and risks of resistance development.