In Vitro Analysis of Finasteride Activity Against Candida Albicans Urinary Biofilm Formation and Filamentation

    July 2014 in “ Antimicrobial Agents and Chemotherapy ”
    Alba Chavez-Dozal, Livia Lown, Maximillian Jahng, Carla J. Walraven, Samuel S. Lee
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    TLDR Finasteride effectively prevents biofilm formation and treats preformed biofilms, but requires high doses.
    The study investigated the effectiveness of finasteride against Candida albicans urinary biofilm formation and filamentation. The results showed that finasteride alone was highly effective in preventing biofilm formation and treating preformed biofilms. Finasteride also exhibited synergistic activity in combination with fluconazole. However, high doses of finasteride were required, limiting its clinical utility. The study suggests that targeting virulence factors, such as biofilm formation and filamentation, may be a potential strategy for treating C. albicans infections.
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