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60-90 / 1000+ resultsresearch A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy
This study found that vismodegib promotes Basal cell carcinoma regression by inducing tumor differentiation but leaves a small population of quiescent cells that can drive relapse, which can be eliminated by adding a Wnt signaling inhibitor.
research Hedgehog Signaling in Papillary Fibroblasts Is Essential for Hair Follicle Regeneration during Wound Healing
This study observed that Hedgehog signaling in reticular and papillary fibroblast lineages plays different roles in wound repair and de novo hair follicle formation.
research The stiffness of the extracellular matrix is a key factor in tumor progression
This study by Bansaccal et al. found that skin with higher levels of type I collagen density and elasticity in the dermis can inhibit basal cell carcinoma development and spread by acting as a natural barrier against cell reprogramming in mice.
research Multimodal Recruitment for an Internet-Based Pilot Study of Ovulation and Menstruation (OM) Health
In the Ovulation and Menstruation Health Pilot Study, multimodal recruitment strategies effectively increased racial diversity and survey completion rates for studying menstrual disorders like PCOS.
research Woodhouse-Sakati syndrome (WSS)
This report describes three Saudi sisters with Woodhouse-Sakati syndrome, who exhibited typical features of the condition along with unusual gynecological anomalies.
research SCAR DUE TO SULFUR MUSTARD GAS ON THIGH WITH CHERRYANGIOMAS, DECREASED HAIR GROWTH AND PIGMENTARYDISORDER: A CASE REPORT
research Treatment of Short Anagen Syndrome With Low‐Dose Oral Minoxidil
In this report, two pediatric patients with short anagen syndrome, a condition causing difficulty in growing long scalp hair, showed positive responses to low‐dose oral minoxidil treatment.
research Postpartum depression: Prevention and multimodal therapy
This article discusses postpartum depression, highlighting the necessity of antenatal and postnatal screening and individualized treatment plans to improve outcomes for mothers and children, but reports no new results.
research Case report: A novel splice-site mutation of MTX2 gene caused mandibuloacral dysplasia progeroid syndrome: the first report from China and literature review
This study reports the first case of mandibuloacral dysplasia syndrome associated with MTX2 gene mutation in the Chinese population, expanding the known spectrum of MTX2 mutations.
research A practical guide on Polyendocrine Metabolic Ovarian Syndrome (PMOS) for Clinicians
This review discusses the proposed shift from PCOS to PMOS, emphasizing a comprehensive approach to diagnosis and management, but reports no new clinical results.
research Early Postpartum Symptoms Differ Between Older and Younger First‐Time Mothers
This study observed that first-time mothers reported a gradual decrease in postpartum symptoms from an average of 7 at one month to 5.3 at three months, with pervasive issues like lack of energy and irritability, especially among older mothers.
research Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
This study found that Msx2-deficient mice exhibit skull and bone formation defects similar to those seen in human MSX2-related conditions, highlighting the gene's importance in skeletal and organ development.
research Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis
research Genome-wide analysis of Musashi-2 targets reveals novel functions in governing epithelial cell migration
This study found that Musashi-2 regulates mRNA targets to restrict epithelial cell migration, revealing a key function of Msi2 beyond its known role in promoting cell growth.
research Identification of somatic and germline mosaicism for a keratin 5 mutation in epidermolysis bullosa simplex in a family of which the proband was previously regarded as a sporadic case
This study describes a case of epidermolysis bullosa simplex where maternal somatic and germline mosaicism was identified, highlighting the significance for genetic counseling in sporadic cases.
research Normal Pubertal Development in Daughters of Women With PCOS: A Controlled Study
In this study, daughters of women with PCOS and control daughters showed no significant differences in metabolic and hormonal parameters, but more PCOS daughters exhibited hirsutism at advanced pubertal stages.
research Mouse Intestinal Krt15+ Crypt Cells Are Radio-Resistant and Tumor Initiating
This study demonstrates that Krt15 marks long-lived, multipotent, and injury-resistant crypt cells in the small intestine, which may serve as the cell of origin in intestinal cancer.
research Trichostasis Spinulosa Confirmed by Standard Skin Surface Biopsy
This case report suggests that Trichostasis spinulosa should be considered in diagnosing treatment-resistant open comedone-like lesions and that skin surface biopsy might be an effective diagnostic method.
research Expanding the Cutaneous Spectrum of Nicolaides‑Baraitser Syndrome: Eczema and Generalized Hair Loss
This case report of a four-year-old girl with Nicolaides-Baraitser syndrome highlights severe atopic dermatitis and worsening alopecia, suggesting that SMARCA2 dysfunction may impact skin barrier integrity and hair health, necessitating aggressive dermatologic treatment.
research Autosomal dominant monilethrix with incomplete penetrance due to a novel KRT86 mutation in a Chinese family
research From PCOS to PMOS: The Impact of Physical Activity, Diet, and Metabolic Health on the Course of Polyendocrine Metabolic Ovarian Syndrome
This review discusses evidence that regular physical activity and tailored dietary interventions improve metabolic health in women with PMOS, advocating for personalized lifestyle management in their care, and reports no new clinical results.
research Rabson-Mendenhall syndrome: two case reports and a brief review of the literature
This report describes Rabson-Mendenhall syndrome cases in two siblings and briefly reviews the literature, highlighting insulin receptor gene mutations as the underlying cause.
research Counselling regarding paternal exposures: Can we do better?
This study found that paternal exposures accounted for a small fraction of calls to the MotherSafe service, and highlighted the lack of reliable information on paternal exposures in publicly available resources.
research Smurf2-induced degradation of SMAD2 causes inhibition of hair follicle stem cell differentiation
This study found that SMAD2 overexpression in human hair follicle stem cells promoted differentiation and apoptosis while inhibiting proliferation, and Smurf2 upregulation limited mouse wound healing by suppressing the SMAD2/NANOG/DNMT1 axis.
research `Cyclic alopecia' inMsx2mutants: defects in hair cycling and hair shaft differentiation
In this study, Msx2-deficient mice showed progressive hair loss due to shortened anagen phase and prolonged catagen and telogen phases, resulting in cyclic alopecia with structurally abnormal hair shafts.
research Satoyoshi syndrome: A rare multisystemic disorder requiring systemic and symptomatic treatment
This case study reports successful treatment of a 19-year-old with Satoyoshi syndrome using a combination of carbamazepine, methotrexate, prednisolone, and sex-steroids, improving muscle spasms, alopecia, and quality of life.
research Follicular mucinosis associated with pregnancy
This correspondence discusses follicular mucinosis in association with pregnancy but does not report new clinical results, instead calling attention to the observed connection.
research Policistisko olnīcu sindroms pusaudzēm – starppaaudžu, ģenētiskie, dzīves kvalitātes un negausīgas ēšanas aspekti. Promocijas darbs
This study found no predictive link between mothers’ PCOS symptoms and the adolescent phenotype, but identified certain gene alleles associated with higher testosterone levels in affected adolescents.
research MTS를 이용한 두피관리가 갱년기 여성의 탈모개선에 미치는 영향
This study found that scalp care using micro-needle therapy was effective in improving hair density and thickness in middle-aged women with menopausal symptoms compared to a control group.