Polycystic Ovary Syndrome in Adolescents: Intergenerational, Genetic, Quality of Life, and Binge Eating Aspects. Dissertation

October 2022

Lāsma Līdaka

polycystic ovary syndrome PCOS testosterone body mass index binge eating body hair genetic analysis BMI

Studysummary This study found no predictive link between mothers’ PCOS symptoms and the adolescent phenotype, but identified certain gene alleles associated with higher testosterone levels in affected adolescents. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated intergenerational, genetic, quality of life, and binge eating aspects in adolescents with polycystic ovary syndrome (PCOS). It included 57 adolescents with PCOS and their mothers, as well as additional groups for genetic analysis. The research found no predictive link between mothers' PCOS symptoms and their daughters' PCOS phenotypes. Certain gene variations were associated with higher testosterone levels in PCOS patients. Key factors affecting health-related quality of life (HRQoL) in adolescents with PCOS were the diagnosis itself, the degree of binge eating, and body mass index percentile, with concerns about body hair and weight being significant. No difference in binge eating frequency was found between PCOS patients and controls. The study highlighted the need for further research with larger samples and longitudinal data to better understand PCOS development over time.

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Research cited in this study

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research Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing

68 citations , January 2022 in “International Journal of Molecular Sciences”

This review summarizes factors involved in polycystic ovary syndrome pathogenesis and management, highlights commonly prescribed and repurposed medications, and calls for well-designed clinical trials to evaluate these treatments further.

research Association of Estrogen Receptor Gene Variants (ESR1 and ESR2) with Polycystic Ovary Syndrome in Tunisia

9 citations , March 2020 in “Gene”

In this study, certain genetic variations in the ESR1 and ESR2 genes were strongly associated with polycystic ovary syndrome and related metabolic issues in Tunisian women.

research Curtailing Polycystic Ovary Syndrome: A Review of International Evidence-Based Guidelines and Implications

43 citations , October 2019 in “Pediatric Research”

This review discusses the International Evidence-Based PCOS Guidelines, which aim to improve diagnosis and management of PCOS and its associated comorbidities, noting the importance of early intervention and healthy lifestyle changes; it reports no new results.

research Psychological Aspects of Hyperandrogenic States in Late Adolescent and Young Women

30 citations , March 2015 in “Clinical Endocrinology”

This study found that late adolescent and young women with clinical hyperandrogenism, including PCOS, experienced higher psychological distress and impaired well-being compared to their healthy peers.

research Metabolic Risk in PCOS: Phenotype and Adiposity Impact

162 citations , January 2015 in “Trends in Endocrinology and Metabolism”

This review discusses how women with PCOS have an increased risk of insulin resistance and cardiometabolic features regardless of body fat, and calls for targeted prevention and management strategies.

The Prevalence of Polycystic Ovary Syndrome in a Normal Population According to the Rotterdam Criteria Versus Revised Criteria Including Anti-Mullerian Hormone

research The Prevalence of Polycystic Ovary Syndrome in a Normal Population According to the Rotterdam Criteria Versus Revised Criteria Including Anti-Mullerian Hormone

221 citations , January 2014 in “Human Reproduction”

This study found that the prevalence of polycystic ovary syndrome was 16.6% with Rotterdam criteria but decreased to 6.3% or 8.5% when using alternative criteria involving antral follicle count or anti-Müllerian hormone.

research CYP21A2 Mutations in Women with Polycystic Ovary Syndrome

9 citations , February 2013 in “Hormone and Metabolic Research”

This study reported that CYP21A2 heterozygous mutations do not significantly contribute to the pathogenesis of polycystic ovary syndrome.

research Metabolic and Reproductive Characteristics of First-Degree Relatives of Women with Self-Reported Oligo-Amenorrhea and Hirsutism

6 citations , October 2010 in “Gynecological Endocrinology”

This study found that relatives of women with symptoms of oligo-amenorrhoea and hirsutism experienced higher rates of hirsutism, menstrual disorders, infertility, childlessness, diabetes, and hypertension compared to relatives of symptomless women.

research Nonclassic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency: Pathophysiology, Diagnosis, and Treatment

49 citations , January 2010 in “International Journal of Pediatric Endocrinology”

This review covers the pathophysiology, diagnosis, and treatment of nonclassic congenital adrenal hyperplasia due to P450c21, but it reports no new clinical results.

research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

1540 citations , October 2008 in “Fertility and Sterility”

This review discusses the definition of polycystic ovary syndrome proposed by the AE-PCOS Society Task Force, emphasizing hyperandrogenism, ovarian dysfunction, and excluding related disorders, while noting potential variations needing more research.

A Prospective Study of the Prevalence of Nonclassical Congenital Adrenal Hyperplasia Among Women Presenting with Hyperandrogenic Symptoms and Signs

research A Prospective Study of the Prevalence of Nonclassical Congenital Adrenal Hyperplasia Among Women Presenting with Hyperandrogenic Symptoms and Signs

150 citations , November 2007 in “The Journal of Clinical Endocrinology and Metabolism”

This study determined that nonclassical congenital adrenal hyperplasia has a 2.2% prevalence among hyperandrogenic women in Spain, with basal serum 17-hydroxyprogesterone showing excellent diagnostic performance.

Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

research Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

1744 citations , August 2006 in “The Journal of Clinical Endocrinology and Metabolism”

This review discusses definitions of polycystic ovary syndrome and reports no new clinical results; the authors support using modified 1990 NIH criteria and acknowledge ongoing evolution as research advances.

Health-Related Quality of Life in Women with Polycystic Ovary Syndrome: A Comparison with the General Population Using the Polycystic Ovary Syndrome Questionnaire and the Short Form-36

research Health-Related Quality of Life in Women with Polycystic Ovary Syndrome: A Comparison with the General Population Using the Polycystic Ovary Syndrome Questionnaire and the Short Form-36

167 citations , January 2006 in “Gynecological Endocrinology”

This study found that women with polycystic ovary syndrome reported a poorer health-related quality of life compared to women in the general population and patients with other medical conditions.

research Prevalence of CYP21 Mutations and IRS1 Variant Among Women With Polycystic Ovary Syndrome and Adrenal Androgen Excess

40 citations , February 2005 in “Fertility and Sterility”

This study suggests that although the G972R variant of the IRS1 gene might increase AA excess risk in heterozygous carriers with CYP21 mutations, both variations play a limited role in PCOS development.

research Androgen Excess in Women: Experience with Over 1000 Consecutive Patients

947 citations , February 2004 in “The Journal of Clinical Endocrinology and Metabolism”

In this study, polycystic ovary syndrome was the most prevalent cause of androgen excess, and suppressive hormonal therapy improved hirsutism, menstrual dysfunction, and acne in most patients, though side effects were common.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

4809 citations , January 2004 in “Fertility and Sterility”

This review discusses polycystic ovary syndrome, emphasizing its broad range of manifestations and associations with risks like type 2 diabetes and cardiovascular events, but reports no new clinical results.