Polycystic Ovary Syndrome in Adolescents: Intergenerational, Genetic, Quality of Life, and Binge Eating Aspects. Dissertation

October 2022

Lāsma Līdaka

polycystic ovary syndrome PCOS testosterone body mass index binge eating body hair genetic analysis BMI

TLDR Adolescents with PCOS have lower quality of life due to diagnosis, binge eating, and body image concerns.

The study investigated intergenerational, genetic, quality of life, and binge eating aspects in adolescents with polycystic ovary syndrome (PCOS). It included 57 adolescents with PCOS and their mothers, as well as additional groups for genetic analysis. The research found no predictive link between mothers' PCOS symptoms and their daughters' PCOS phenotypes. Certain gene variations were associated with higher testosterone levels in PCOS patients. Key factors affecting health-related quality of life (HRQoL) in adolescents with PCOS were the diagnosis itself, the degree of binge eating, and body mass index percentile, with concerns about body hair and weight being significant. No difference in binge eating frequency was found between PCOS patients and controls. The study highlighted the need for further research with larger samples and longitudinal data to better understand PCOS development over time.

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Research cited in this study

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research Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing

68 citations , January 2022 in “International Journal of Molecular Sciences”

PCOS management includes lifestyle changes and medications, with ongoing research into repurposed drugs for better treatment options.

research Association of Estrogen Receptor Gene Variants (ESR1 and ESR2) with Polycystic Ovary Syndrome in Tunisia

9 citations , March 2020 in “Gene”

Certain gene variants in estrogen receptors are linked to polycystic ovary syndrome, mainly affecting metabolism, in Tunisian women.

research Curtailing Polycystic Ovary Syndrome: A Review of International Evidence-Based Guidelines and Implications

43 citations , October 2019 in “Pediatric Research”

Lifestyle changes are the main treatment for PCOS, which is a complex condition requiring early management to reduce its health impacts.

research Psychological Aspects of Hyperandrogenic States in Late Adolescent and Young Women

30 citations , March 2015 in “Clinical Endocrinology”

Young women with high male hormone levels or PCOS often feel more psychological distress and have a lower quality of life.

research Metabolic Risk in PCOS: Phenotype and Adiposity Impact

162 citations , January 2015 in “Trends in Endocrinology and Metabolism”

Women with PCOS face higher risks of diabetes and heart disease, and these risks increase with obesity.

The Prevalence of Polycystic Ovary Syndrome in a Normal Population According to the Rotterdam Criteria Versus Revised Criteria Including Anti-Mullerian Hormone

research The Prevalence of Polycystic Ovary Syndrome in a Normal Population According to the Rotterdam Criteria Versus Revised Criteria Including Anti-Mullerian Hormone

221 citations , January 2014 in “Human Reproduction”

Adding anti-Müllerian hormone to PCOS criteria lowers the number of women diagnosed.

research CYP21A2 Mutations in Women with Polycystic Ovary Syndrome

9 citations , February 2013 in “Hormone and Metabolic Research”

Mutations in the CYP21A2 gene are not a major factor in causing PCOS.

research Metabolic and Reproductive Characteristics of First-Degree Relatives of Women with Self-Reported Oligo-Amenorrhea and Hirsutism

6 citations , October 2010 in “Gynecological Endocrinology”

Relatives of women with PCOS symptoms are more likely to have similar health issues.

research Nonclassic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency: Pathophysiology, Diagnosis, and Treatment

49 citations , January 2010 in “International Journal of Pediatric Endocrinology”

The document concludes that Nonclassic Congenital Adrenal Hyperplasia requires personalized treatment plans to manage symptoms and fertility, with glucocorticoids being a common therapy.

research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

1540 citations , October 2008 in “Fertility and Sterility”

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

A Prospective Study of the Prevalence of Nonclassical Congenital Adrenal Hyperplasia Among Women Presenting with Hyperandrogenic Symptoms and Signs

research A Prospective Study of the Prevalence of Nonclassical Congenital Adrenal Hyperplasia Among Women Presenting with Hyperandrogenic Symptoms and Signs

150 citations , November 2007 in “The Journal of Clinical Endocrinology and Metabolism”

About 2.2% of women with symptoms of high male hormones have a mild form of congenital adrenal hyperplasia, and measuring a specific hormone level can accurately diagnose it.

Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

research Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

1744 citations , August 2006 in “The Journal of Clinical Endocrinology and Metabolism”

Polycystic Ovary Syndrome should be seen mainly as a condition of excess male hormones, with a focus on this in its definition.

Health-Related Quality of Life in Women with Polycystic Ovary Syndrome: A Comparison with the General Population Using the Polycystic Ovary Syndrome Questionnaire and the Short Form-36

research Health-Related Quality of Life in Women with Polycystic Ovary Syndrome: A Comparison with the General Population Using the Polycystic Ovary Syndrome Questionnaire and the Short Form-36

167 citations , January 2006 in “Gynecological Endocrinology”

Women with PCOS have lower quality of life, especially in mental health and energy, and managing weight can help improve it.

research Prevalence of CYP21 Mutations and IRS1 Variant Among Women With Polycystic Ovary Syndrome and Adrenal Androgen Excess

40 citations , February 2005 in “Fertility and Sterility”

Some women with PCOS have CYP21 mutations and IRS1 variants, but these genetic factors are not major contributors to PCOS.

research Androgen Excess in Women: Experience with Over 1000 Consecutive Patients

947 citations , February 2004 in “The Journal of Clinical Endocrinology and Metabolism”

Most women with excess male hormones have Polycystic Ovary Syndrome, and hormonal therapy can improve symptoms but may cause side effects.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

4809 citations , January 2004 in “Fertility and Sterility”

The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.