1 citations
,
May 2026 in “Nature Communications” This study demonstrated that CD19-CAR T cell therapy may promote structural regeneration in the skin of systemic sclerosis patients, as evidenced by histological improvements and fibroblast population changes, suggesting its potential for tissue remodeling in fibrotic diseases.
37 citations
,
May 2004 in “Multiple Sclerosis Journal” This article highlights adverse skin reactions due to injectable therapies for MS, noting that while generally mild, some cases can progress to serious lesions requiring medical intervention.
3 citations
,
February 2025 in “Frontiers in Cell and Developmental Biology” Wharton's Jelly stem cell medium may help treat skin issues in Systemic Sclerosis.
July 2023 in “Journal of skin and stem cell” In this study conducted at Baqiyatullah Hospital, it was found that interferon beta (IFNβ) treatment in multiple sclerosis patients commonly led to skin complications, with injection site erythema being most frequent, and also increased hair loss severity.
July 2025 in “Journal of Investigative Dermatology” This study found that high-dose UVA-1 therapy appeared to improve both patient-reported outcomes and objective clinical measures in patients with morphea and systemic sclerosis, supporting its potential efficacy for treating scleroderma.
January 2005 in “Linchuang pifuke zazhi” In this study, transfection of the VEGF165 gene increased hair growth and rejuvenated the atrophic dermis in a mouse model of sclerotic skin.
This study suggests that skin tumor cells in tuberous sclerosis complex may promote hamartoma morphogenesis by expressing and releasing higher levels of cathepsin B.
142 citations
,
August 2015 in “Arthritis & Rheumatology” This study found significant heterogeneity in transcriptome patterns among SSc patients, identifying prominent fibroinflammatory and keratin signatures that may aid in stratifying patients for targeted treatment approaches.
January 2022 in “Medical research archives” This article reviews the potential role of vitamin D supplementation as an adjunct to alemtuzumab therapy in multiple sclerosis management, noting its possible benefits for autoimmune comorbidities and patient adherence, but reports no new clinical results.
1 citations
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March 2019 in “Journal of Interdisciplinary Medicine” This case report details a middle-aged man with multiple sclerosis who developed difficult-to-evaluate skin reactions after daclizumab treatment, noting only slight improvement with additional therapies.
January 2005 in “Di-san junyi daxue xuebao” This study found that VEGF significantly promoted hair follicle growth and regeneration in mice with scleroderma.
53 citations
,
August 2017 in “Journal of Investigative Dermatology” 5 citations
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January 2016 in “European Journal of Dermatology” Suplatast tosilate successfully treated a woman's systemic sclerosis symptoms.
32 citations
,
July 2017 in “Molecular diagnosis & therapy” MicroRNA-21 could help diagnose and treat skin fibrosis.
142 citations
,
March 2019 in “Molecules/Molecules online/Molecules annual” This review discusses the role of the endocannabinoid system in skin health and disease, highlighting its potential for future research and applications, but reports no new experimental results.
26 citations
,
October 2017 in “Clinical Reviews in Allergy & Immunology” This review explores skin manifestations associated with autoimmune liver diseases and highlights known and probable links, such as vitiligo's strong association with autoimmune hepatitis.
24 citations
,
March 2018 in “Experimental Dermatology” This review explores the role of regulatory T cells in autoimmune skin disorders like alopecia areata and vitiligo, emphasizing unanswered questions and reporting no new experimental results.
15 citations
,
November 2024 in “Journal of Advanced Research” In this study, researchers found that miR-3606-3p is significantly downregulated in skin fibrosis and correlates with disease severity, with its ability to inhibit key signaling pathways suggesting potential therapeutic applications for conditions like systemic sclerosis and keloids.
6 citations
,
April 2023 in “Cosmetics” In this review, researchers explored the potential of exosomes in cosmetics, skincare, tissue regeneration, and dermatological treatment, noting their promising ability to modulate cellular environments, potentially improving skin health and treating various skin conditions.
3 citations
,
September 2024 in “The FASEB Journal” This review discusses the roles of dermal white adipose tissue in skin functions and pathology, underscoring its antibacterial activity and potential anti-fibrotic role, but reports no new experimental results.
1 citations
,
October 2025 in “International Journal of Nanomedicine” This review explores the potential for using exosomes in treating autoimmune skin diseases and promoting skin regeneration, highlighting current applications, delivery methods, and ongoing clinical trials while also identifying challenges and future research directions within dermatology.
The document concludes that dermatology training and grading scales need to better represent dark-skinned individuals to improve diagnosis and assessment of skin conditions.
September 2024 in “Journal of Ayurveda and Integrative Medicine” This case report detailed a 45-year-old woman with diffuse systemic sclerosis who underwent Ayurvedic treatment, leading to reduced depigmentation, new hair growth, and improved well-being over eight weeks. The findings suggest the potential efficacy of a holistic Ayurvedic approach in managing scleroderma symptoms.
This pilot study found that a high fat lard diet may protect against fibrosis and affect the hair follicle cycle in a mouse model of systemic sclerosis, unlike a high fat coconut oil diet.
January 2024 in “Rheumatology quarterly” This research highlights the essential role of skin findings in diagnosing and managing rheumatic diseases, emphasizing their importance in early recognition, classification, and treatment planning, which requires collaboration between rheumatologists and dermatologists.
January 2021 in “Springer eBooks” This chapter reviews skin manifestations in common rheumatic diseases, particularly those with polyarthritis, and offers a differential diagnosis of erythema nodosum without presenting new research findings.
April 2017 in “Journal of Investigative Dermatology” In this study, HPH-15, a newly synthesized compound, demonstrated potential in reducing skin fibrosis in a mouse model by targeting underlying pathogenic mechanisms and exhibited a good safety profile, warranting further clinical trials for fibrotic skin disorders like systemic sclerosis.
4 citations
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July 2019 in “Clinics in Dermatology” This article reviews various "white diseases" characterized by hypopigmentation or depigmentation and emphasizes the role of melanosomes in skin and eye color, but it does not present new clinical results.
April 2023 in “Journal of Investigative Dermatology” In this systematic review, researchers found that individuals with lichen sclerosus have a higher prevalence of comorbidities like vitiligo, alopecia areata, and cardiovascular diseases compared to non-affected controls, and suggest screening all LS patients for cardiovascular risk factors and other diseases.
September 1999 in “The Journal of The British Menopause Society” This review discusses how menopause and hormone replacement therapy affect skin aging in women but reports no new clinical findings.