The Effects of Transfection of Human VEGF165 Gene with Electroporation Technique into Bleomycin-Induced Sclerotic Skin in Mice
January 2005
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Linchuang pifuke zazhi
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New to Vascular Endothelial Growth Factor? There is a guide in the encyclopedia. Read the guide → Studysummary In this study, transfection of the VEGF165 gene increased hair growth and rejuvenated the atrophic dermis in a mouse model of sclerotic skin. Our plain-language summary of this paper — not a Tressless recommendation.
The study aimed to evaluate the therapeutic effect of transfecting the human VEGF165 gene into bleomycin-induced sclerotic skin in mice using an electroporatic technique. The results showed that transgenic mice exhibited increased hair growth on their backs compared to non-transgenic mice, with a significant increase in the number of hair follicles (12.0±1.6/field). Additionally, there was increased thickness and angiogenesis of the dermis, and enhanced expression of the VEGF165 gene in the epidermis and dermis. The study concluded that the electroporatic technique effectively transfected the exogenous gene into sclerotic skin, promoting hair growth and renewing atrophic dermis in mice.
