A Systematic Review and Meta-Analysis of Comorbidities in Lichen Sclerosus With a Screening Recommendation

    April 2023 in “ Journal of Investigative Dermatology ”
    S. Suler Baglama, G.B. Jemec, K. Trčko
    Image of study
    TLDR People with Lichen sclerosus are more likely to have skin conditions like vitiligo and alopecia areata, heart disease risks, and other health issues. They should be checked for these, but screening plans shouldn't differ based on gender due to lack of data.
    The systematic review and meta-analysis of 15 case-control studies found that patients with Lichen sclerosus (LS), regardless of gender, had significantly higher odds of having vitiligo, alopecia areata, and cardiovascular risk factors and diseases compared to non-LS controls. Females with LS also had higher odds of having atopic dermatitis and psoriasis, which was not the case for males with LS. The study also found higher odds for various other diseases in LS patients, including skin, thyroid, liver and kidney diseases, certain rheumatic, upper respiratory, gastrointestinal, ophthalmic and psychiatric diseases, genital infections, tension type headache and coagulopathies. However, these were not studied in both genders. The study concluded that all LS patients should be screened for cardiovascular risk factors, depression, genital infections, thyroid, liver and kidney diseases as well as coagulopathies, but gender-dependent screening strategies in LS are currently not reasonable due to limited data.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 37 results

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 2 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

      community Making the jump to hair systems

      in Hair Systems  27 upvotes 3 years ago
      19-year-old with Lichen Planopilaris tried various treatments unsuccessfully. Now considering hair systems, seeking experiences and opinions.

      community Anger and frustration as I finally learn my diagnosis.

      in Female  6 upvotes 1 year ago
      A young female diagnosed with Lichen planopilaris (LPP) experienced years of misdiagnosis and ineffective treatments, including a hair transplant and other procedures. She is considering litigation due to the misdiagnosis and has learned that LPP is chronic, hair loss can be stopped with ongoing medication, but lost hair cannot regrow.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Clascoterone (Winlevi) Update for Canada

      in Treatment  16 upvotes 2 years ago
      Clascoterone cream was submitted for review to Health Canada in August 2022, with hopes of approval within 3-6 months. It may potentially enhance finasteride's effects for hair loss treatment.

    Related Research

    2 / 2 results