1 citations
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October 2022 in “Curēus” This case report highlights the challenges in diagnosing simple-virilizing congenital adrenal hyperplasia, emphasizing the importance of early expert evaluation to prevent irreversible changes such as virilization.
June 2023 in “Medicine and Pharmacy Reports” A woman with a specific mutation causing adrenal gland issues faced fertility problems, but careful hormone therapy helped her manage it successfully.
December 2024 in “Journal of Clinical Research in Pediatric Endocrinology” This study explains that congenital adrenal hyperplasia due to 21-hydroxylase deficiency presents as a continuous phenotype and involves symptoms ranging from virilization to accelerated growth in children, with diagnosis relying on clinical, biochemical, and genetic evaluation.
January 2017 in “Elsevier eBooks” Congenital Adrenal Hyperplasia is mainly caused by enzyme deficiencies, leading to varying symptoms like hormone imbalances and physical changes.
This review discusses the clinical forms and causes of androgenization in women, as well as therapeutic options, reporting success with antiandrogens like cyproterone acetate and spironolactone for skin symptoms, though results are not permanent.
1 citations
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September 2017 in “Zhonghua neifenmi daixie zazhi” This article discusses the importance of routine karyotyping in patients with congenital adrenal hyperplasia, as it may reveal the presence of Turner syndrome and recommends early diagnosis and treatment; it reports no new clinical results.
April 2023 in “Research Square (Research Square)” This case study of a young Palestinian woman illustrates the diagnostic and treatment challenges of ovarian steroid cell tumors, highlighting the importance of detailed examination when hormonal therapy fails.
April 2023 in “Research Square (Research Square)” This case report highlights a Palestinian woman with a rare ovarian steroid cell tumor, underscoring the diagnostic challenges and potential for disease progression despite treatment attempts with various chemotherapy regimens.
27 citations
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April 2017 in “European journal of endocrinology” This retrospective study found that serum hormone levels and MRI detection of ovarian nodules contributed to distinguishing virilizing ovarian tumors from ovarian stromal hyperthecosis in postmenopausal women, though histopathology remains crucial for diagnosis.
6 citations
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January 2010 in “Case Reports” This study describes the case of a Filipino woman with virilisation, where a rare ovarian Leydig cell tumour was identified and removed, normalizing her testosterone levels.
4 citations
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November 2018 in “Journal of Pharmaceutical and Biomedical Analysis” This study found that a hydro-alcoholic extract of Roselle petals may reduce free radical production during UV-induced photodecomposition of antibiotics, potentially offering protective benefits for patients using similar topical antibiotics.
September 2025 in “Reproductive health of woman” This study found that in women with polycystic ovary syndrome, taking metformin for three months significantly reduced serum levels of luteinizing hormone, follicle-stimulating hormone, and testosterone, suggesting a beneficial effect on managing hyperandrogenism.
2 citations
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July 2023 in “AACE Clinical Case Reports” In this case study, researchers identified a Leydig cell tumor in a 56-year-old postmenopausal woman with virilization symptoms by using ovarian vein sampling, as imaging was nonrevealing, and confirmed the tumor's location using testosterone ratios, which supported previous findings.
20 citations
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October 2017 in “Clinical Endocrinology” This article reviews existing knowledge on postmenopausal hyperandrogenism and highlights diagnostic challenges, reporting no new clinical results.
8 citations
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April 2019 in “Journal of the Endocrine Society” In this study, long-term normalization of testosterone levels in postmenopausal women with hyperandrogenism did not improve body mass index, glucose, or lipid metabolism.
6 citations
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March 2021 in “Frontiers in surgery” This case report describes a 64-year-old woman with hirsutism who was found to have a borderline adrenocortical oncocytoma, successfully treated with adrenalectomy.
14 citations
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March 2022 in “Clinical Endocrinology” This review outlines a diagnostic approach for identifying non-PCOS pathology in women with androgen excess, emphasizing the importance of clinical history and biochemical phenotyping but reports no new clinical results.
6 citations
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January 2011 in “PubMed” This paper reviews hair loss associated with various endocrine disorders and describes both traditional and emerging non-invasive diagnostic methods without presenting any new clinical results.
November 2022 in “Journal of the Endocrine Society” This case report describes a rare instance of virilizing androgen production due to an ovarian serous cystadenoma in a 59-year-old woman, with testosterone levels normalizing after its removal.
3 citations
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May 2025 in “Clinical Endocrinology” Evaluate and manage androgen excess in women with a systematic approach, considering both physical and psychological impacts.
July 2023 in “Endocrinology, diabetes & metabolism case reports” This case report involved a premenopausal woman with rapidly progressing virilizing symptoms caused by a rare sertoliform endometrioid carcinoma of the ovary. Following surgical intervention, her symptoms improved, highlighting the importance of recognizing virilizing symptoms as potential indicators of low-grade ovarian malignancies in similar cases.
1 citations
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July 2019 in “The journal of applied laboratory medicine” This review analyzes 873 cases of female hyperandrogenism, primarily attributing it to polycystic ovarian syndrome, and explores sample testing for suspected neoplasms but reports no new clinical findings.
31 citations
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February 1997 in “The Journal of Clinical Endocrinology and Metabolism” This study concluded that heterozygosity for CYP21 mutations is associated with higher mean and free testosterone levels in women but does not significantly increase their risk of developing clinically evident hyperandrogenism.
11 citations
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August 2019 in “The Journal of Sexual Medicine” This study found that women with nonclassic congenital adrenal hyperplasia (NC-CAH) reported lower sexual function and higher sexual distress compared to those with classic CAH (C-CAH), particularly among those showing signs of androgen excess.
5 citations
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May 2019 in “Hormone and Metabolic Research” This study reported that in embryo transfer cycles for women with nonclassic 21-hydroxylase deficiency, dexamethasone use was associated with improved pregnancy rates, and maintaining a BMI below 23.36 kg/m² increased pregnancy probabilities.
11 citations
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January 2016 in “The Journal of Sexual Medicine” This study found that young women with nonclassic congenital adrenal hyperplasia had impaired sexual function and mild depressive symptoms compared to healthy women.
9 citations
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February 2019 in “Journal of Clinical Research in Pediatric Endocrinology” In this study, children with classical congenital adrenal hyperplasia were found to have increased epicardial fat thickness, which was associated with subclinical atherosclerosis markers and left ventricular dysfunction, especially in poorly controlled cases.
14 citations
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August 2014 in “Applied Physiology, Nutrition, and Metabolism” This study concluded that an 8-week low-starch/low-dairy diet increased fat oxidation in overweight and obese women with PCOS.
54 citations
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February 1993 in “Endocrine reviews” This review examines the physiological role of androgen conjugates in cutaneous androgen metabolism and questions their association with hirsutism, without presenting new clinical findings.
18 citations
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January 2015 in “Journal of obesity and weight loss therapy” This study found that an 8-week low-starch/low-dairy diet led to weight loss, improved insulin sensitivity, and reduced testosterone levels in women with PCOS.