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The document concludes that hormone therapy is essential for treating gender dysphoria, with specific drugs and monitoring protocols recommended for safety and effectiveness.

Adding estrogen increased bone mass in a transsexual man undergoing hormone therapy.

The skin acts like an endocrine organ, producing hormones that affect various body functions and skin health, and understanding this can lead to new treatments.

Lower SHBG levels may increase the risk of PCOS.

SHBG may be a useful early indicator and treatment target for PCOS.

SHBG binding properties are unchanged in male liver cirrhosis patients.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

Men and women experience skin aging differently due to changes in sex hormone levels with age.

New genes and pathways are important for testosterone production and male sexual development.

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.

Certain genetic variations in the SHBG gene are linked to an increased or decreased risk of PCOS in Mediterranean women.

Finasteride reduces alcohol withdrawal severity in male mice but increases it in female mice.

Sex hormones affect brain injury differently in males and females.

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Cyclosporine A therapy changes sex hormone levels differently in pre-menopausal and post-menopausal women with primary biliary cirrhosis.

Some ovarian tumors can cause masculinization, and it's important to check for various causes when this symptom is present.

Testosterone, progesterone, and levonorgestrel change enzyme levels related to fat production in hamster skin, which could affect skin oil and acne.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Women with PCOS who have low SHBG are more likely to have low good cholesterol and metabolic syndrome.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.

Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.