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Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.

Sex hormones may influence COVID-19 severity, with males at higher risk, and certain hormone therapies could potentially treat the virus.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

Androgens like testosterone affect hair growth and oil production differently across body parts and individuals.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

Metformin taken during pregnancy increases SHBG in newborns but doesn't change other hormone levels in mothers or babies.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

Finasteride reduces inflammation and improves immune response after trauma by altering hormone levels.

Skin diseases linked to insulin resistance should be managed to prevent diabetes and reduce heart disease risk.

Women with low SHBG levels and a high 3a-diol G to SHBG ratio are likely to experience female pattern baldness, possibly due to a slight excess of androgens affecting sensitive hair bulbs.

Vitamin D and estrogen may help protect heart and kidney health, and maintaining sufficient vitamin D levels could be especially beneficial for African Americans, postmenopausal women, and people with chronic kidney disease.

Testosterone helps human pancreatic cells increase insulin release.

Hormone therapy may increase migraines in transgender women and decrease them in transgender men; more research is needed on migraine management in transgender individuals.

Arab hair is generally thicker but less dense compared to other ethnicities, affecting hair disorder diagnosis and treatment.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Female rats showed more panic-related behavior than males, influenced by hormonal cycles and certain drugs.

The document concludes that ideal facial proportions are guided by specific measurements and symmetry to enhance beauty, but individual characteristics must be considered.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Men need higher doses and tailored injection techniques for botulinum toxin treatments due to their unique facial features.

The document concludes that individualized Facial Feminization Surgery plans and comprehensive care are crucial for successful outcomes.

Eczema and fungal infections are the most common skin problems in Japan, with different age groups and genders affected by various conditions.

Men, diabetes, and high inflammation levels lead to higher COVID-19 antibodies.

Men prefer less invasive cosmetic procedures and need different treatment approaches than women.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Gender identity can be more diverse than just male or female.

Scalp skin barrier affects hair loss; personalized treatments needed.

Prolactin may affect hair growth differently based on gender and scalp area.

Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.

17-β-Estradiol applied to the skin stops hair growth, while ICI 182 780 helps hair grow in mice.