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Blocking CRF1 receptors improved male hormone levels and reduced testicular tumor size in men with a specific adrenal condition.

Scientists restored fertility in male mice lacking a key fertility gene by using a modified gene.

The testes produce sperm and hormones essential for male development.

More research is needed to understand how testosterone is maintained in adult males.

HNG may help prevent the negative effects of chemotherapy on sperm production and white blood cell counts.

Cell transplantation faces challenges in genitourinary reconstruction, but alternative tissue sources and microencapsulation show promise.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.

Testicular microlithiasis may increase the risk of testicular cancer and patients with it should be closely monitored.

The document explains how male reproductive hormones work and affect the body.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

COVID-19 might affect male fertility, but more research is needed to understand the full impact.

Cross-sex hormone therapy is important for managing gender dysphoria and requires careful monitoring and healthcare provider education.

Finasteride in male rats causes liver and metabolic issues in their offspring.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

Managing oxidative stress might help treat low testosterone and related chronic diseases in aging men.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

COVID-19 may harm male fertility and damage the reproductive system.

Men, particularly those with hair loss, are more likely to get the virus, and those with prostate cancer may have milder symptoms. Testosterone's role in the disease is unclear, and the virus doesn't seem to harm male fertility. Women with PCOS might be at higher risk. More research is needed.

The document does not determine if adults with aphallia are fertile.

Long COVID causes a wide range of long-lasting symptoms that change over time and are hard to diagnose and treat.

Basonuclin 2 is vital for the development of facial bones, hair follicles, and male germ cells in adult mice, and its absence can lead to dwarfism and abnormal follicles.

SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.

Testosterone may have a dual role in COVID-19, potentially worsening outcomes in men, and testosterone therapy could help some patients, but more research is needed.

Testosterone may influence COVID-19 severity and outcomes.

Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.

Antioxidants may help improve mitochondrial health and could be used to treat diseases related to cell damage.

Flutamide caused damage to male rat reproductive organs and may affect fertility.