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Metformin improves menstrual cycles and hormone levels in women with PCOS, mostly within the first 6 months.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

Finasteride shows promise for female hair loss, but more research needed.

Premature ovarian insufficiency (POI) can harm women's sexual health, and they may benefit from hormone therapy and counseling.

Different tea tree oil mixtures absorb into hair follicles at varying levels, with microemulsion being the most effective.

Spironolactone is better than placebo for reducing excessive hair growth in women, but its effectiveness for acne is unclear due to small study sizes.

Testosterone therapy may slightly improve sexual function in postmenopausal women, but its long-term safety is unknown.

Late puberty may slightly lower prostate cancer risk, baldness is not linked to overall risk but less so with aggressive types, ibuprofen use may increase risk, and vitamins show no effect on risk.

South Asian women with PCOS present with different symptoms compared to White women, influenced by ethnicity, obesity, and age.

Sensitive skin often causes discomfort, affects many people, especially women and older adults, and should be managed with careful product selection.

Vegetarian Indian women with PCOS have higher inflammation levels than non-vegetarians.

Combining electrodynamic microneedle with 5% minoxidil improves hair growth and reduces hair loss in Chinese men.

Men with baldness at the front and top of their head at age 45 may have a higher risk of aggressive prostate cancer.

Testosterone therapy can improve sexual desire and function in postmenopausal women but should be used cautiously and not based solely on testosterone levels.

Cognitive behavioral strategies help women with PCOS make lifestyle changes to improve their health.

Most Latino farmworkers in the study had skin diseases, with fungal infections being the most common.

Adults with certain skin conditions may have higher levels of inflammation in their body.

Testosterone therapy and surgeries like mastectomy improve transgender men's lives and mental health with low risks and high satisfaction.

The document concludes that it's important to understand the placebo effect when evaluating the effectiveness of treatments in medical trials.

Laser and light treatments can effectively remove hair long-term.

Oral contraceptives lower testosterone levels in women, especially those with certain genetic traits, and may be linked to increased breast cancer risk.

Age, smoking, and lower BMI increase facial wrinkles; men wrinkle more than women, except in old age; pale skin and certain hormonal factors can protect against wrinkles.

Certain SHBG gene variants, like rs727428, are linked to higher testosterone levels in women with PCOS.

The document suggests a new model for evaluating public research that better captures the full value of knowledge creation and use, using PCOS research as an example.

All treatments reduce hair growth; low dose flutamide most effective with fewer side effects.

Taking finasteride for benign prostate hyperplasia may increase the risk of osteoporosis, especially at higher doses.

Managing PCOS is hard because it varies a lot, treatments are limited, and there's a lot of false information online.

The review highlights the need for more research on transgender dermatology, the role of dermatologists in gender affirmation, and the effects of hormone therapy on skin and hair.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

Cognitive-behavioral therapy is the best treatment for hair-pulling disorder, and combining it with other therapies could improve results.