This review discusses the link between selenium levels in the environment and related diseases in China, reporting no clinical results; the authors highlight the need for clearer geographic risk and remediation strategies.
August 2026 in “International Journal of Nanomedicine” This review discusses the transformation of selenium nanoparticles into multifunctional platforms for skin disease treatment, focusing on engineering principles rather than their intrinsic bioactivity alone, and reports no new clinical results.
September 2025 in “ACS Applied Polymer Materials” This study reported that a composite hydrogel made with Chlorella-derived extracellular polysaccharide–selenium nanoparticles showed strong antibacterial and anti-inflammatory effects in vitro and significantly accelerated wound healing in vivo, offering potential for managing infected wounds and monitoring healing progression.
May 2025 in “Journal of Dermatological Treatment” This study found that a medicated shampoo containing selenium sulfide and salicylic acid effectively reduced symptoms of seborrheic dermatitis in Chinese patients, but females experienced significantly lower rates of good effectiveness and tolerance compared to males.
March 2025 in “Skin Appendage Disorders” In this study, selenium disulfide shampoo was found to reduce dandruff severity and rebalance the scalp microbiome in individuals with all hair types experiencing moderate to severe dandruff, with subjects reporting high satisfaction and good tolerance over a 6-week period.
September 2024 in “Journal of the American Academy of Dermatology” This introduction highlights that a common challenge with managing dandruff, a mild form of seborrheic dermatitis, is compliance with treatment, and notes that selenium disulfide shampoo is beneficial for this condition.
February 2024 in “Exposure and Health” Selenium supplements may reduce mercury levels in the hair of city dwellers in China.
February 2024 in “Animals” This study found that supplementing pregnant Hanshan white cashmere goats' diets with selenium yeast led to higher birth weights, improved cashmere quality and yield, and enhanced hair follicle development in their offspring, possibly through increased antioxidant capacity.
September 2023 in “Food and chemical toxicology” In this study on Sprague-Dawley rats, 0.60 mg/kg doses of L-Se-methylselenocysteine and sodium selenite were associated with liver toxicity and reduced sperm motility, while Se-enriched peptides showed no observable adverse effects up to 0.60 mg/kg.
May 1990 in “ThinkTech (Texas Tech University)” This review discusses the cytotoxic effects of various selenium compounds on human mammary tumor cells and explores the impact of selenium and magnesium in dietary studies with nude mice, reporting no new clinical results.
September 1980 in “PubMed” This study found that applying a surfactant solution with 2.5% selenium disulfide to the back of guinea pigs significantly increased telogen hair, which may relate to observations of diffuse hair loss in humans under intense exposure conditions.
January 2023 in “Research Square (Research Square)” In this study, CoQ10 and selenium nanoparticles showed potential to alleviate hyperlipidemia and simvastatin-induced side effects in rats, but a triple combination with simvastatin caused intense liver and muscle damage.
12 citations
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December 1962 in “Journal of Investigative Dermatology” July 2026 in “Journal of the American Academy of Dermatology” January 2005 in “Zhonghua xingwei yixue yu naokexue zazhi” This study found that long-term selenium and iodine deficiencies in rats led to growth delays and abnormal neural behavior by the fourth generation.
14 citations
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January 1984 in “Nutrition reports international” October 2009 in “The American Journal of Gastroenterology” This report describes a case where selenium supplementation in excess may have led to toxic liver injury, suggesting that high-dose selenium can cause hepatic necrosis.
May 2014 in “The Journal of Alternative and Complementary Medicine” Higher levels of chromium, selenium, and copper in hair are linked to increased insulin resistance in visceral-obese adults.
This study found that certain concentrations of sodium fluoride accelerated apoptosis in cultured human hair follicles, while sodium selenite could counteract this toxicity in vitro.
21 citations
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April 2009 in “Trace Elements and Electrolytes” This study found that autistic children had significantly lower iron levels and higher selenium levels in their hair compared to healthy peers, with variations observed between autistic boys and girls.
134 citations
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December 2018 in “Dermatology and Therapy” This review discusses the potential role of vitamins and minerals in managing non-scarring alopecia but reports no clinical results; the authors advocate for further controlled trials to explore these relationships.
125 citations
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May 2010 in “Pediatric dermatology” This review presents European guidelines for treating tinea capitis, noting systemic antifungals are essential, with griseofulvin preferred for Microsporum infections and newer antifungals viable for Trichophyton but often costlier.
79 citations
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January 2017 in “Dermatology practical & conceptual” This article addresses the need to screen for nutrient deficiencies in patients with hair loss but reports no new findings, noting that supplementation without deficiency may not be beneficial and could pose risks.
70 citations
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June 2010 in “Clinics in Dermatology” This review discusses how changes in hair and skin may indicate underlying vitamin deficiencies and emphasizes the need to identify populations at risk for these deficiencies; it reports no new results.
66 citations
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November 1997 in “Nutrition” This study found that while micronutrient abnormalities are common among patients receiving home parenteral nutrition, serious consequences from these abnormalities are rare.
65 citations
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August 2016 in “Metabolic brain disease” This study found that children with autism spectrum disorder generally have lower levels of both essential and toxic trace elements in their hair compared to controls.
63 citations
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May 2017 in “American Journal of Clinical Dermatology” This review found that patients with alopecia areata may have lower levels of vitamin D, zinc, and folate, but conflicting evidence precludes definitive clinical recommendations for micronutrient supplementation.
63 citations
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March 2000 in “Annals of clinical psychiatry” This article reviews the association between psychopharmaceuticals and medication-induced alopecia, noting that hair regrowth typically occurs after discontinuing or reducing the medication, while mineral supplements' effectiveness remains unclear.