A Selenium Disulfide-Based Shampoo Is Beneficial For Dandruff Management And Rebalancing The Scalp Microbiome Of Subjects Of Any Hair Type

March 2025 in “ Skin Appendage Disorders ”

Pascal Reygagne, Claire Deloche-Bensmaine, Stéphanie Leclerc‐Mercier, Julien Fauré, Natalia Kovylkina, Cécile Clavaud, Audrey Guéniche, Victoria Barbosa

selenium disulfide dandruff scalp microbiome erythema itching SeS2 dandruff shampoo

TLDR Selenium disulfide shampoo effectively reduces dandruff and improves scalp health for all hair types.

The study evaluated the effects of selenium disulfide (SeS2) shampoo on dandruff and scalp microbiome balance across various hair types. Conducted over 6 weeks with 93 adult participants (83% women, 69% European, 31% African), the study found that SeS2 shampoo significantly reduced dandruff severity, erythema, and itching, with improvements noted after 4 weeks (p<0.05). The shampoo also effectively rebalanced the scalp microbiome (p<0.001) and was well tolerated by all subjects, who reported high satisfaction with its use. The study highlights SeS2 shampoo as a beneficial treatment for moderate to severe dandruff in all hair types.

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