Effectiveness and Tolerance of Medicated Shampoo Containing Selenium Sulfide and Salicylic Acid in Patients with Seborrheic Dermatitis

    May 2025 in “ Journal of Dermatological Treatment ”
    Lei Wang, Huijuan Liu, Nuo Li, Ying Wang, Qingwu Liu, Yijie Zheng, Dingquan Yang, Wenyu Wu
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    TLDR The shampoo improved seborrheic dermatitis symptoms, but worked better for males than females.
    This study involving 560 patients with seborrheic dermatitis found that a medicated shampoo containing selenium sulfide and salicylic acid significantly improved dandruff, scalp redness, itching, and greasiness over 21 days. However, females reported lower effectiveness (87.5% vs. 93.6%) and tolerance (93.9% vs. 99.6%) compared to males, suggesting gender differences in treatment response due to factors like scalp sensitivity and sebum production. The study emphasizes the need for tailored treatments for females and acknowledges limitations such as self-reported data and a cross-sectional design, which restrict causal conclusions. Future research should employ longitudinal designs and objective scalp health measures.
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