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This study suggests that fibromodulin may regulate transforming growth factor-β activity during scar formation, influencing the transition from fetal scarless repair to adult scar-forming repair in rats.

In this study, fetal rat wounds at gestational age 16 days healed without scar formation and resembled normal skin architecture, unlike those at 18 days which resulted in scarring and lack of hair follicles.

In this study, aged mice showed better regenerative skin outcomes than young mice, linked to a specific fibroblast subpopulation and enhanced signaling interactions that promote regeneration. EREG treatment improved young mice's skin regeneration, suggesting potential for scarless therapies.

This study found that hydrogen peroxide interfered with scarless healing in a murine fetal wound repair model, potentially by inducing transforming growth factor-beta1, which may contribute to increased fibrosis.

This review discusses the mechanisms of scar formation and current strategies for scar-free wound healing, reporting no new clinical results and emphasizing the need for further research.

This review discusses the unique features of fetal wound healing that may enable scarless repair and reports no new experimental findings.

Fetuin-A helps wounds heal without scars by promoting cell movement.

This review highlights the unique scarless wound healing abilities of fetuses and discusses potential applications to adult wound healing, reporting no new experimental findings.

In this study, researchers observed that abdominal wounds in laboratory rats healed faster, completing epithelialization in 20 days versus 30 days for back wounds, possibly due to a higher expression of skin stem cell marker genes in the abdominal area.

This review categorizes contractile hydrogels by their contraction mechanisms and explores their role in advanced wound management, emphasizing mechanical and biochemical signaling in healing, but also notes challenges like force transmission and clinical applicability.

In this study, a multifunctional aloin-arginine-alginate bio-patch was developed, which transforms into a hydrogel to accelerate wound healing and offers antibacterial and anti-inflammatory benefits, making it promising for use in cutaneous regeneration.

This review discusses the differences in wound healing between fetal and adult skin, highlighting the potential to uncover genes for scarless repair that could improve adult wound healing.

This chapter highlights the potential of exosomes as innovative agents in cosmetic dermatology, noting their ability to promote skin rejuvenation and target issues like wrinkles, photoaging, and hair loss.

This review discusses the roles of key developmental signaling pathways in mammalian skin repair compared to skin development, and suggests these insights could lead to better wound healing therapies, but it reports no new findings.

This chapter reviews classic regeneration models in planarian worms and amphibian limbs, focusing on the role of stem cells, and reports no new experimental results.

This article is a collection of book reviews in the International Journal of Cosmetic Surgery and Aesthetic Dermatology and presents no new clinical findings.

This study found that fibroblasts play a crucial role in scar formation during dermal development and identified N-Cadherin as a key molecule in their response, suggesting new therapeutic avenues for scar prevention.

This review explores current knowledge on fibroblast lineage specification and its impact on scar-free wound healing, noting that early fetal skin fibroblasts support regeneration, while later developmental shifts lead to fibrosis, highlighting potential strategies to reprogram adult fibroblasts for regenerative repair.

This study reports that a new artificial skin system using multi-layered hydrogels can promote scarless wound healing and regenerate appendages like hair follicles without cell transplantation.

This study reviews current research on skin repair and regeneration, highlighting promising methods such as stem cell therapies, nanotechnology, and skin substitutes, which may enhance healing and resistance to environmental damage.

In this review, biomaterial-based mechanical strategies were highlighted for their potential to enhance skin regeneration and promote scarless repair, though a comprehensive understanding of their underlying mechanisms is still needed for broader application.

In this study, MSC-laden silk nanofiber hydrogels accelerated wound healing and enabled scarless skin regeneration with hair follicles, outperforming MSC-free hydrogels in repairing full-thickness skin defects.

This review discusses recent advances in scarless wound healing, focusing on strategies to create pro-regenerative scaffolds for repairing damaged skin, and reports no new clinical results.

This review discusses the typical wound healing process in skin and the oral cavity, and emphasizes the research focus on achieving scarless healing in adult skin, but reports no new clinical results.

This study using a mouse model reports that CuATSM treatment accelerates skin wound healing and reduces scar formation, with effects possibly mediated via the ferroptosis-induced Hippo/YAP signaling pathway and macrophage polarization, suggesting CuATSM as a potential therapy for scarless wound healing in clinical settings.

In this review, retinoids are highlighted as promising agents for promoting scarless skin regeneration by coordinating cellular and molecular processes that suppress fibrosis, enhance re-epithelialization, promote angiogenesis, and enable hair follicle formation, potentially advancing functional skin repair.

In this study, researchers used a chemical cocktail and hydrogel microspheres to successfully guide fibroblasts into dermal papilla cells, promoting wound healing and in situ hair follicle regeneration while reducing scar formation, in both in vitro and in vivo experiments.

This symposium discussed why regenerative capacity varies among species and diminishes with age, exploring how these insights could inform regenerative medicine approaches, without presenting new experimental results.

This chapter reviews skin components, wound healing mechanisms, and the potential of biomaterials to enhance skin repair and regeneration, without offering new experimental results.

This review presents an overview of the integrated organ systems involved in wound healing and reports no new findings; the authors emphasize the roles of blood coagulation, immune response, and cellular mechanisms in tissue repair.