150 citations
,
February 2013 in “Surgical Infections” This review discusses the historical and modern use of silver for reducing infections and aiding healing in burns, wounds, and medical devices, noting its benefits and limitations in various applications.
150 citations
,
December 2012 in “EMBO Reports” This review explores the mechanisms of adult stem cell self-renewal, using skin as a model, and reports no new results but raises important unanswered questions in the field.
150 citations
,
October 2012 in “Clinical Endocrinology” In this retrospective cohort study, women with polycystic ovary syndrome showed high incidence and age-specific prevalence rates of type 2 diabetes, myocardial infarction, and angina, particularly in those over 65.
150 citations
,
April 2008 in “Journal of The American Academy of Dermatology” This study found that videodermoscopy reveals distinct dermoscopic features in patients with alopecia areata incognita, aiding in biopsy decisions by identifying the appropriate sampling area and potentially avoiding unnecessary procedures.
150 citations
,
February 2008 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study suggests that antiandrogens may slightly reduce hirsutism severity compared to placebo, but evidence is weak and their relative efficacy remains uncertain.
150 citations
,
November 2007 in “The Journal of Clinical Endocrinology and Metabolism” This study determined that nonclassical congenital adrenal hyperplasia has a 2.2% prevalence among hyperandrogenic women in Spain, with basal serum 17-hydroxyprogesterone showing excellent diagnostic performance.
150 citations
,
July 2001 in “Clinics in dermatology” This article discusses hair care practices and hair cosmetics in managing alopecia but reports no new clinical findings; it emphasizes the importance of scalp health and good patient-physician communication.
150 citations
,
August 1992 in “Genes & Development” This study reported that transgenic mice with targeted TNF alpha expression in keratinocytes showed impaired weight gain, retarded hair growth, and skin changes, leading to cachexia and necrosis.
149 citations
,
September 2017 in “Pharmaceutics” This review compares animal and human skin characteristics in in vitro permeation studies but reports no new results, highlighting variations and the need for better model correlations.
149 citations
,
July 2014 in “Cold Spring Harbor Perspectives in Medicine” This article provides contact information for Bruce A. Morgan and features no new research findings.
149 citations
,
January 2011 in “Nature reviews. Urology” Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.
149 citations
,
December 2007 in “The Journal of Clinical Endocrinology and Metabolism” Women with PCOS have overall higher body fat, not abnormal fat placement, and more insulin resistance.
149 citations
,
April 2013 in “Drug Safety” 148 citations
,
August 2022 in “Stem Cell Research & Therapy” This study found that encapsulating hADSCs-derived exosomes in PF-127 hydrogel improved wound healing in mice, suggesting a promising approach for enhancing skin repair.
148 citations
,
May 2012 in “The American Journal of Human Genetics” This study identified heterozygous mutations in the ABCC9 gene as the genetic basis of Cantú syndrome, suggesting the syndrome as a new member of potassium channelopathies.
148 citations
,
April 2009 in “Molecular Pharmaceutics” This study reports that three synthesized PSMA-targeted radioimaging agents demonstrated high affinity and specific localization to prostate cancer tumors in a mouse model, highlighting their potential for cancer detection and monitoring.
148 citations
,
May 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that mice lacking the vitamin D receptor (VDR) developed skin tumors more rapidly than those with normal VDR activity, regardless of 1,25-dihydroxyvitamin D(3) presence.
147 citations
,
October 2021 in “Cancer Communications” This study found that the novel anti-HER2 antibody RC48 demonstrated promising activity and manageable safety in patients with HER2-overexpressing, advanced gastric or gastroesophageal junction cancer after at least two prior chemotherapy lines.
147 citations
,
September 2006 in “Developmental Cell” This study found that Smad7 perturbs hair follicle development while promoting sebaceous gland formation by antagonizing Wnt/β-catenin signaling in transgenic mice.
147 citations
,
October 2004 in “Experimental dermatology” This paper reviews the role of androgens in human skin function and the challenges in developing treatments for androgen-associated disorders, reporting no new experimental results.
147 citations
,
April 2004 in “PubMed” This study identifies specific localization patterns of androgen, estrogen, and progesterone receptors in human skin, which could be crucial for understanding their roles in skin biology and pathology.
146 citations
,
January 2004 in “Hormones” This review explores the complex endocrine functions of human skin and its role as a peripheral endocrine organ, but reports no new clinical results.
145 citations
,
November 2018 in “Nature Communications” This study found that activating the Sonic hedgehog pathway in scarring wounds can remodel the dermis to promote hair follicle regeneration, highlighting a potential new approach to enhance healing.
145 citations
,
December 1999 in “Journal of Investigative Dermatology Symposium Proceedings” Finasteride 1mg helps reverse hair miniaturization in men and postmenopausal women.
144 citations
,
November 2020 in “Frontiers in immunology” This study summarizes how the IL-23/IL-17 axis contributes to inflammatory skin diseases like psoriasis and highlights that biologics targeting this pathway, including monoclonal antibodies against IL-23 and IL-17, have shown efficacy in clinical trials for these conditions.
144 citations
,
August 2019 in “Cells” This review discusses the WNT signaling pathway's involvement in human diseases and highlights recent advances in WNT-related treatments, but it presents no new research findings.
144 citations
,
July 2015 in “Clinical, Cosmetic and Investigational Dermatology” This review reports that alopecia areata affects about 2% of people globally and is linked with psychiatric and medical comorbidities, highlighting its significant disease burden.
144 citations
,
March 2013 in “Circulation Research” This study reports that mutations in the SUR2 gene are linked to Cantu syndrome, highlighting the role of KATP channels in cardiovascular health and potential new therapies.
144 citations
,
September 2012 in “Genes & development” This study found that aging in the epidermis disrupts cytokine balance and stem cell function, which may contribute to broader tumor-suppressive mechanisms.
144 citations
,
September 2006 in “Clinics in Dermatology” This article outlines manifestations of systemic lupus erythematosus, noting rapid joint symptom improvement with corticosteroids and antimalarial drug responsiveness for skin symptoms, and links anti-Ro with photosensitive rash and subacute lupus.