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Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

RXR-alpha is strongly expressed in both normal and psoriatic skin and may help in skin cell differentiation and hair growth.

Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.

Basal cell carcinomas have much higher levels of Vitamin D3 receptors compared to healthy skin.

Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.

Alitretinoin may help treat alopecia areata.

The R343H mutation in the VDR gene causes vitamin D-resistant rickets with alopecia by impairing specific gene activity.

Increased PPARGC1α relates to hair thinning in common baldness.

Stem cells help remove dead cells to keep tissues healthy by balancing cell replacement and clearance.

The vitamin D receptor can work without its usual activating molecule.

Two different mutations in the vitamin D receptor gene cause different symptoms and responses to treatment in Lebanese patients with hereditary rickets.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

Researchers created a mouse model of a type of rickets that does not cause hair loss.

An 82-year-old man's white hair regained color after taking etretinate for psoriasis.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

Vitamin D receptor is crucial for starting hair growth after birth.

Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.