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Certain metabolites are lower in women with PCOS and could be potential markers for the condition.

Disrupting Smad4 in mouse skin causes early hair follicle stem cell activity that leads to their eventual depletion.

Scientists created early-stage hairs from mouse cells that grew into normal, pigmented hair when implanted into other mice.

A hair wrapped tightly around an infant's toe caused severe damage, requiring early removal and possibly surgery to prevent worse outcomes like amputation.

People with androgenetic alopecia have more personality disorders and mental health symptoms; treatment may help.

Germ-free rats need biotin for growth and have different vitamin metabolism compared to regular rats.

Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.

Drug repositioning is becoming more targeted and efficient with new technologies, offering personalized treatment options and growing interest in the field.

Adding hyaluronic acid helps create larger artificial hair follicles in the lab.

Caffeine nanocrystals for skin products stay stable with the right stabilizer, but grow in size at higher temperatures.

The research found that polycystic ovary syndrome (PCOS) has two distinct types, with one having more severe hormone and insulin issues.

The document concludes that correct diagnosis and management of PCOS are important, and more research is needed on its risks and treatments.

New hair products are being developed to keep hair and scalp healthy for everyone.

FUE provides minimal scarring and quick recovery in hair transplantation, and surgeons not using it may lag in technology.

Growing hair follicles have high mitochondrial activity and ROS in specific regions, aiding hair formation.

Some women with PCOS have CYP21 mutations and IRS1 variants, but these genetic factors are not major contributors to PCOS.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

Different lab conditions and light treatment methods change how human skin cells respond to light therapy.

Improved Finasteride delivery for hair loss treatment.

Certain genetic variations in the SHBG gene are linked to an increased or decreased risk of PCOS in Mediterranean women.

GLI2 increases follistatin production in human skin cells.

Behavioral dermatology treats skin problems by considering both emotional and physical factors.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Nanoparticles with more oleic acid improved the delivery and stability of the drug spironolactone.

The document concludes that identifying the cause of amenorrhea is crucial for proper treatment.

Women with only irregular periods or excess hair have a better hormone profile than those with full PCOS, but both groups are similar, indicating a need for better PCOS diagnosis methods.

Patient had scalp allergy from minoxidil; test helped identify cause and suggest alternative treatments.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Finasteride effectively improves hair growth and slows hair loss in men with male pattern baldness.

The current system can't fully test all combination treatments, so alternative methods and regulatory flexibility are needed.