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Targeted cancer therapies often cause serious skin problems that need careful management.

Some herbal therapies may help with skin conditions, but more research is needed to confirm their safety and effectiveness.

Hormone treatments in transsexual individuals reduce hair growth and oil production in male-to-females and increase them in female-to-males.

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Generalized pustular psoriasis patients often need strong medication and careful treatment due to flare-ups and complications.

Coal tar shampoos, salicylic acid, and topical corticosteroids are effective for scalp psoriasis, with Vitamin D3 analogues also showing benefits; severe cases may require stronger medication with more risks.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

JAK inhibitors help with skin conditions but need more research on dosing and safety.

Liposomes could improve how skin care products work but are costly and not very stable.

Flutamide may slightly improve hair loss in women, but finasteride does not work.

Overexpressing Dsg3 in mice skin causes excessive cell growth and abnormal skin development.

Recombinant cytokine therapy can cause skin reactions ranging from mild to severe.

Mouflon rams mature gradually with changes in body, horns, and hormones linked to age and seasons, reaching full sexual maturity well after puberty.

New antifungal treatments for a children's scalp infection are effective and safe, but it's not decided if they will become the preferred option over the old treatment.

Mutant mice help researchers understand hair growth and related genetic factors.

Methotrexate reduced the need for steroids in asthma patients without worsening their condition.

Vitiligo affects overall health and self-esteem, needing more research and awareness.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

New treatments for Alopecia Areata, like JAK inhibitors, show promise for hair regrowth and are likely to change future treatment approaches.

Polycystic ovarian shape is a genetic sign of PCOS and its hormonal and metabolic features can be inherited.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

Some systemic treatments work for nail psoriasis but can have serious side effects.

Lithium therapy may cause skin problems like hidradenitis suppurativa and other side effects, which can improve after stopping the medication.

LED therapy is safe and shows potential for treating skin conditions and promoting hair growth, but more research is needed.

Both mouse and rat models are effective for testing alopecia areata treatments.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

The most common hair loss type at specialist clinics is androgenetic alopecia, especially in younger men, followed by alopecia areata and telogen effluvium, with differences seen across regions.

Different hair care practices and conditions affect African American hair and scalp health, requiring specialized knowledge for treatment.