Ovarian Morphology Is a Marker of Heritable Biochemical Traits in Sisters with Polycystic Ovaries

    June 2008 in “ The Journal of Clinical Endocrinology and Metabolism ”
    Stephen Franks, Lisa Webber, Micaela Goh, A. P. Valentine, Davinia White, Gerard S. Conway, Steven Wiltshire, Mark I. McCarthy
    Image of study
    TLDR Polycystic ovarian shape is a genetic sign of PCOS and its hormonal and metabolic features can be inherited.
    The study from September 2008 investigated the heritability of polycystic ovarian morphology and associated biochemical traits in families affected by Polycystic Ovary Syndrome (PCOS). It included 125 probands with PCOS and 214 sisters, of which 151 were affected and 63 were unaffected. The findings indicated that affected sisters had similar biochemical profiles to the probands, including serum testosterone, androstenedione, LH, fasting insulin, and insulin sensitivity levels, despite having fewer symptoms. The heritability of these traits was moderate to high among affected sisters but was significantly lower in discordant sibling pairs. This suggests that polycystic ovarian morphology is a strong genetic marker of PCOS and that the condition's endocrine and metabolic features are heritable.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 12 results

      community My scalp punch biopsy results🤔?

      in Female  9 upvotes 1 year ago
      Female using Rogaine foam for hair loss had scalp punch biopsy, diagnosed with Androgenetic Alopecia (AGA). Doctor recommended starting Spironolactone 50mg.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Bryan Johnson just dropped his anti hair loss formula

      in Treatment  339 upvotes 10 months ago
      Bryan Johnson shared his hair loss treatment, which mainly relies on minoxidil and finasteride. Some users are skeptical of his results, while others appreciate his efforts in anti-aging and hair loss research.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  53 upvotes 1 year ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community having hair loss as a teen SUCKS. A LOT.

      in Female  12 upvotes 2 years ago
      A teenage girl who has been diagnosed with ADA and is struggling with hair loss, which has caused her to lose confidence. She is looking for recommendations on treatments such as finasteride or Minoxidil, and lifestyle advice including vitamins and other supplements that might help with the issue.

    Similar Research

    6 / 1000+ results