July 2025 in “Frontiers in Medicine” In this systematic review and meta-analysis, the authors examined single-spin versus double-spin centrifugation protocols for PRP in patients with androgenic alopecia and found no significant difference in platelet concentration, hair density, or hair types between the protocols.
15 citations
,
May 2018 in “Open Access Macedonian Journal of Medical Sciences” This double-blind control study found that an ointment containing propolis (50%) and aloe vera (3%) led to significant improvement in 64.4% of patients with mild to moderate psoriasis over 12 weeks, compared to no significant improvement in the placebo group.
1 citations
,
December 2021 in “Journal of drugs in dermatology” In this double-blind study, a novel hyaluronic acid gel for lip augmentation was found to be as effective and safe as a commercially available gel, with similar adverse event profiles and high patient and investigator improvement ratings over six months.
1 citations
,
January 2021 in “Indian Dermatology Online Journal” This expert group provided recommendations for preparing and using platelet-rich plasma in treating androgenetic alopecia, suggesting a manual double-spin method and specific dosing, although further studies on injectable platelet-rich fibrin are needed.
9 citations
,
November 2021 in “PubMed” This study found that FDA-approved low-level light/laser therapy devices significantly increased hair density in individuals with pattern hair loss compared to sham devices.
29 citations
,
September 2020 in “Polymers” This study found that electrospun poly(ε-caprolactone)/poly(3-hydroxybutyrate) blend fibers demonstrated nanometric dimensions and promising properties for drug delivery, with curcumin release linked to fiber morphology and processing parameters.
21 citations
,
January 2019 in “Lasers in Medical Science” This review found that low-level laser therapy significantly increased hair density in adults with androgenic alopecia compared to sham treatments, with greater effects observed at lower treatment frequencies.
80 citations
,
August 1991 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This study found that low-dose methotrexate significantly reduced the steroid requirement in subjects with corticosteroid-requiring asthma without altering their clinical status or causing significant complications.
23 citations
,
July 1989 in “Postgraduate medical journal” This study found that spironolactone 100 mg daily did not demonstrate objective benefits in managing idiopathic hirsutism, as it increased hair shaft diameter without reducing serum androgen levels.
3 citations
,
January 1985 in “British Journal of Dermatology” In this study, a low concentration zinc sulphate solution was investigated for managing recurrent herpes simplex infections, but no new clinical results were reported.
7 citations
,
March 2019 in “Dermatologic surgery” In this randomized trial, bimatoprost 0.01% significantly improved eyebrow hair density and diameter in patients with eyebrow hypotrichosis compared to a placebo, with minimal adverse effects, suggesting it is an effective and safe treatment option.
In this study, botulinum toxin type A injections reduced the severity of treatment-resistant scalp psoriasis in more patients compared to placebo over a 12-week period.
May 2011 in “Value in Health” This study found that the oral Janus kinase inhibitor CP-690,550 has a direct effect on reducing pruritus in patients with psoriasis, independent of clinician-assessed improvements in psoriasis severity.
18 citations
,
August 1985 in “European journal of endocrinology” This study found that high-dose cyproterone acetate was effective for treating hirsutism, but 33% of patients felt their condition worsened on low-dose maintenance therapy, despite no significant change in objective measures of hair growth.
16 citations
,
January 2000 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study found that serum PSA levels are higher in hirsute women and can be significantly reduced by antiandrogen treatment, suggesting PSA as a marker of androgen action in females.
90 citations
,
August 2002 in “European journal of endocrinology” This study found that metformin treatment significantly improved hair growth in women with PCOS and hirsutism compared to a placebo.
3 citations
,
May 2019 in “Journal of Cosmetic Dermatology” This study found that a 12-week supplementation with MePL, a solution of miliacin encapsulated within polar lipids, significantly reduced hair density in the telogen phase and improved scalp dryness and hair brightness in women with telogen effluvium.
June 2003 in “Obstetrical & Gynecological Survey” This study observed that the size of vaginal prolapse in patients was significantly related to both the preoperative vaginal length and the length of vaginal excision during the Michigan four-wall sacrospinous suspension procedure.
1 citations
,
March 2021 in “Journal of Experimental Biology and Agricultural Sciences” This study observed that consuming flaxseeds significantly reduced serum free testosterone and improved insulin levels among young women with PCOS, suggesting a promising alternative to conventional treatments.
27 citations
,
February 2017 in “Clinical, Cosmetic and Investigational Dermatology” In this study, a topical formulation with compounds from the monoterpenoid family significantly improved hair growth indicators like anagen:telogen ratio, hair fall, and visual hair density in men and women with pattern hair loss.
25 citations
,
November 2008 in “Ophthalmic Plastic and Reconstructive Surgery” This study found no significant differences in sensation recovery or scar formation between radiofrequency and scalpel incisions in upper blepharoplasty, although radiofrequency caused greater tissue damage.
July 2021 in “Open access journal of biomedical science” This study evaluated the effectiveness of a lotion containing Larrea divaricata and Coffea arabica extracts in accelerating hair growth in women after chemotherapy, but it reports no results.
In this study, minoxidil 2% produced satisfactory esthetical results in about 30% of patients, but placebo-treated subjects experienced increased hair counts without a cosmetic benefit, possibly due to seasonal variations and hair classification issues.
69 citations
,
October 2013 in “Journal of Clinical Psychopharmacology” This study found that naltrexone did not significantly reduce hair pulling in adults with trichotillomania compared to placebo, although it improved cognitive flexibility.
32 citations
,
November 2005 in “Journal of Investigative Dermatology Symposium Proceedings” Most women preferred the 1% pyrithione zinc shampoo for better hair smoothness and less frizz while controlling dandruff.
August 2021 in “Asian Journal of Pharmaceutical and Clinical Research” In this randomized trial, a solid shampoo formulated with plant extracts was more effective than placebo in improving androgenetic alopecia and reducing hair cortisol and DHT concentrations in men.
37 citations
,
May 2002 in “PubMed” In this study, long-term use of finasteride did not negatively impact bone mineral density in men with benign prostatic hyperplasia over a 4-year period.
January 2017 in “Nutrafoods - International Journal on Nutraceuticals, Functional Foods and Novel Foods” This study found that a dietary supplement containing fermented soy, ornithine, arginine, and Tricovel® Tricoage45+ significantly reduced hair loss and promoted hair growth in menopausal women after 8 to 12 weeks.
16 citations
,
August 1989 in “PubMed” This study concluded that high-dose oral therapy with L-cystine, gelatin, and vitamin A significantly improved hair growth indicators in patients with diffuse hair loss, with no systemic side effects observed.
May 2026 in “Aesthetic Plastic Surgery” This study found that autologous growth factor injections for androgenetic alopecia improved hair density, thickness, and patient satisfaction over 12 months; however, high bias risk and non-standardized methods limit the evidence's reliability, highlighting the need for larger, standardized trials.