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research Early and midterm outcome after off-pump and on-pump surgery in Beating Heart Against Cardioplegic Arrest Studies (BHACAS 1 and 2): a pooled analysis of two randomised controlled trials
This study found that off-pump coronary surgery significantly reduces in-hospital morbidity compared to on-pump surgery without affecting midterm outcomes in the first 1-3 years after the procedure.
research Study of olive leaf extract on skin aging: Ex vivo, animal, and randomized double-blind placebo-controlled clinical studies
This study found that water extract of olive leaf may enhance markers linked to epidermal and dermal stem cell activity and potentially improve skin aging, especially in individuals who do not exercise regularly.
research The efficacy and safety of JAK inhibitors for alopecia areata: A systematic review and meta-analysis of prospective studies
This study found that oral JAK inhibitors are effective and generally well-tolerated for treating alopecia areata, but high recurrence rates after stopping treatment suggest the need for continuous use.
research Effects of Probiotic Supplementation on Mental Health and the Risk of Depression in Women with Polycystic Ovary Syndrome: A Systematic Review of Randomized Controlled Trials
This systematic review found that probiotic supplementation improved sleep quality, reduced depressive symptoms, and enhanced aspects of quality of life in women with PCOS, though the findings are limited by a small number of studies and variable methods.
research The effects of ginger (Zingiber officinale) supplementation on the hormonal profile, hirsutism, amenorrhea, dysmenorrhea, and hair loss in women with polycystic ovary syndrome: a randomized double-blind, placebo-controlled trial
In this study of women with polycystic ovary syndrome, 12 weeks of daily ginger supplementation significantly reduced total testosterone and improved menstrual irregularities compared to placebo, suggesting potential as a natural therapeutic approach, although larger studies are needed.
research Effects of photobiomodulation therapy for androgenic alopecia: A meta-analysis of randomized controlled trials
This meta-analysis reported that photobiomodulation therapy may improve hair density and stimulate hair growth in patients with androgenic alopecia compared to sham treatments, but larger studies are needed to confirm these findings.
research Efficacy and safety of topical GT20029 in male patients with androgenetic alopecia: a multicenter, randomized, double-blind, placebo-controlled phase 2 study
In this multicenter Phase II trial, researchers found that topical GT20029 significantly increased hair regrowth in Chinese adult males with androgenetic alopecia compared to placebo, demonstrating good tolerability and suggesting the need for further studies to confirm its therapeutic potential.
research Evaluation of the Efficiency of Low-Level Laser Therapy in Female Patients with Chronic Pelvic Pain: A Double-Blind, Randomized, Placebo-Controlled Clinical Study
This study suggests that Low-level Laser Therapy may improve pain and quality of life in women with Chronic Pelvic Pain Syndrome, though larger studies are needed to confirm these findings.
research Management of alopecia areata: Updates and algorithmic approach
This review highlights the diverse prognoses and limited long-term efficacy of current alopecia areata treatments, discussing existing and emerging therapies—including biologics—and proposing an algorithmic management approach based on specific disease characteristics.
research Comment on the Use of Biotin for Hair Loss
Biotin may help women with hair loss who have low biotin levels, but more research is needed.
research 5-Alpha-Reductase Inhibitor Treatment for Frontal Fibrosing Alopecia:A Myth or Truth?
This review discusses frontal fibrosing alopecia and reports no new clinical results; the authors highlight the need for randomized controlled trials on 5AR inhibitors to assess their efficacy and safety.
research Comparison between dutasteride and finasteride in hair regrowth and reversal of miniaturization in male and female androgenetic alopecia: a systematic review
This systematic review concluded that dutasteride was more effective than finasteride in increasing hair count for treating androgenetic alopecia in both males and females, with comparable side effects.
research Platelet-Rich Plasma In Androgenetic Alopecia:An Evidence-Based Clinical And Biological Review
This review discusses the evidence for platelet-rich plasma as a promising treatment for androgenetic alopecia, highlighting its potential benefits and favorable safety profile but noting the need for standardized protocols and larger trials.
research New developments in the molecular treatment of ichthyosis: review of the literature
This review discusses recent advancements in therapies for ichthyosis, highlighting promising prospects in protein replacement and gene therapy, but it reports no new clinical results.
research Cicatricial (Scarring) Alopecias
Scarring alopecias are complex hair loss disorders that require early treatment to prevent permanent hair loss.
research Past, present, and future of global research on artificial intelligence applications in dermatology: A bibliometric analysis
This study used bibliometric analysis to evaluate global research on AI applications in dermatology, identifying 406 relevant papers and highlighting current priorities such as machine learning for wound progression, AI in teledermatology, and applications for skin diseases.
research Homoeopathy a System of Holistic Healing as an Alternative Treatment for PCOS – a Review
This review covers clinical studies on using homoeopathy to treat PCOS and concludes that further rigorous research is necessary to substantiate its effectiveness.
research Evidence for the off-label use of tofacitinib in alopecia areata
This study reviewed various studies and concluded that Janus kinase inhibitors, particularly tofacitinib, seem to promote hair regrowth in about half of patients with alopecia areata, though expected class-specific adverse effects were observed.
research Current application of mesotherapy in pattern hair loss: A systematic review
This study concluded that mesotherapy appears effective for treating pattern hair loss, but emphasizes a need for more research comparing it to other treatments due to limited sample sizes.
research Randomized controlled evaluator blinded study of dutasteride versus finasteride in men with androgenetic alopecia
The research concluded that in men with androgenetic alopecia, dutasteride was more effective than finasteride at increasing hair count after 24 weeks, with similar side effect profiles.
research Alopecia areata update
This review discusses treatment options for alopecia areata and suggests tailored treatment plans, noting the challenges posed by spontaneous remission and limited high-quality clinical trials.
research Efficacy of polyphenolic compounds for hair regeneration: a systematic review and meta-analysis of randomized controlled trials.
This study evaluated the efficacy of polyphenolic compounds for hair growth in adults with non-scarring alopecia and found that these interventions significantly improved hair density and total area hair count compared to controls, although results were not significantly different from minoxidil.
research Randomized Controlled Trial Study to Evaluate the Efficacy of Combination Therapy with Diphenylcyclopropenone and Platelet-Rich Plasmain Alopecia Areaata
This study found that adding PRP to DPCP treatment for severe alopecia areata did not enhance effectiveness compared to DPCP alone.
research A Randomised Controlled Trial Comparing the Therapeutic Efficacy and Safety of Oral Cyclosporine and Oral Betamethasone Minipulse Therapy in the Treatment of Alopecia Areata
This study found that oral cyclosporine therapy was more effective than betamethasone mini-pulse therapy for treating alopecia areata, with a better patient-reported outcome on hair regrowth, despite a higher incidence of mild, reversible adverse effects in the cyclosporine group.
research BH06 (P075) A randomized controlled trial comparing the efficacy and safety of oral tofacitinib vs. methotrexate in moderate-to-severe alopecia areata
This study compared oral tofacitinib and methotrexate in treating moderate-to-severe alopecia areata, finding that tofacitinib was more effective at reducing SALT scores and improving scalp hair assessment PRO scores, though both treatments reduced psychological distress similarly without serious adverse effects.
research P075 A randomized controlled trial comparing the efficacy and safety of oral tofacitinib vs. methotrexate in moderate-to-severe alopecia areata
This study found that both tofacitinib and methotrexate effectively reduced hair loss and psychological distress in patients with moderate-to-severe alopecia areata, but tofacitinib showed much greater efficacy. Both treatments had similar safety profiles, with no serious adverse effects reported.
research The effect of an oral product containing Amla fruit (Phyllanthus emblica L.) on female androgenetic alopecia: A randomized controlled trial
In this triple-blind, randomized clinical trial, researchers found that oral Amla syrup significantly increased the anagen-to-telogen hair ratio and satisfaction levels in women with Female Androgenetic Alopecia compared to placebo, suggesting its potential benefit for treating androgenic hair loss.
research Incidence of serious infectious events with methotrexate treatment: Metaanalysis of randomized controlled trials
This study found that nonobese women with idiopathic hirsutism had significantly lower nitrite/nitrate concentrations and higher fibrinogen levels compared to controls, but similar levels to women with PCOS.
research Titagen® for total wellness: results from a randomised, placebo controlled clinical study on adults for osteoarthritis, improvement in skin, nail and health
In this randomized, placebo-controlled study, Titagen® was found to improve skin, hair, and nail health in adults consuming 5g daily, and reduce pain and improve quality of life for osteoarthritis patients taking 10g daily, without related adverse events.