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    Glossary Protease

    enzyme that breaks down proteins into smaller peptides

    A protease, also known as a proteinase or peptidase, is an enzyme that breaks down proteins into smaller peptides or amino acids by cleaving the peptide bonds between amino acids. These enzymes play crucial roles in various biological processes, including digestion, immune response, and cell regulation.

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    1. Proteasome Inhibitors: An Expanding Army Attacking a Unique Target Chemistry & biology · 2012 · 474 citations
    2. Epidermal differentiation: The role of proteases and their inhibitors European Journal of Cell Biology · 2004 · 118 citations
    3. The mouse frizzy (<i>fr</i>) and rat ‘hairless’ (<i>fr</i><sup><i>CR</i></sup>) mutations are natural variants of protease serine S1 family member 8 (<i>Prss8</i>) Experimental Dermatology · 2010 · 28 citations
    4. The mRNA for Protease Nexin-1 is Expressed in Human Dermal Papilla Cells and its Level is Affected by Androgen Journal of Investigative Dermatology · 1999 · 27 citations
    5. Nagashima-Type Palmoplantar Keratosis: A Common Asian Type Caused by SERPINB7 Protease Inhibitor Deficiency Journal of Investigative Dermatology · 2014 · 24 citations
    6. Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS‐CoV‐2 in the respiratory tract Pharmacology Research & Perspectives · 2020 · 15 citations
    7. The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin‐1 (PN‐1) inhibition The FASEB Journal · 2014 · 14 citations
    8. Protease activity, localization and inhibition in the human hair follicle International Journal of Cosmetic Science · 2013 · 11 citations
    9. Protease-Activated Receptor-1 (Thrombin Receptor) Is Expressed in Mesenchymal Portions of Human Hair Follicle Journal of Investigative Dermatology · 2003 · 7 citations
    10. Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing β-Catenin Stem cells · 2013 · 3 citations
    11. An Integrated Two-Step Enzymatic Unhairing Strategy: Eliminating the Penetration Barrier via Soaking To Enhance Targeted Protease Action Industrial & Engineering Chemistry Research · 2026
    12. Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene Mammalian Genome · 2022
    13. Message of protease nexin-1 is expressed in human dermal papilla cells and is affected by androgen Journal of dermatological science · 1998
    14. Properties of Partially Extracted Hairs and their Degradability by Proteases Sen'i Gakkaishi · 2007
    15. Expression analysis of proteasome maturation protein (<i>POMP</i>) gene in Liaoning Cashmere goat Animal biotechnology · 2019 · 7 citations
    16. Cell Type-specific Functions of the Lysosomal Protease Cathepsin L in the Heart Journal of Biological Chemistry · 2007 · 56 citations
    17. Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity 2019 · 39 citations
    18. Message of nexin 1, a serine protease inhibitor, is accumulated in the follicular papilla during anagen of the hair cycle Journal of Cell Science · 1995 · 37 citations
    19. A Novel Serine Protease Overexpressed in the Hair Follicles of Nude Mice Biochemical and Biophysical Research Communications · 1999 · 32 citations
    20. Keratinocyte-Specific Onset of Serine Protease BSSP Expression in Experimental Carcinogenesis Journal of Investigative Dermatology · 2001 · 26 citations
    21. Colocalization of Cystatin M/E and its Target Proteases Suggests a Role in Terminal Differentiation of Human Hair Follicle and Nail 2008 · 22 citations
    22. Bikunin, a Serine Protease Inhibitor, is Present on the Cell Boundary of Epidermis Journal of Investigative Dermatology · 1999 · 13 citations
    23. The protease corin regulates electrolyte homeostasis in eccrine sweat glands PLoS biology · 2021 · 10 citations
    24. Male balding as a major risk factor for severe COVID-19: A possible role for targeting androgens and transmembrane protease serine 2 to protect vulnerable individuals Journal of The American Academy of Dermatology · 2020 · 6 citations
    25. Growth inhibition of mouse skin tumor by serine protease inhibitor ONO-3403. PubMed · 2001 · 1 citations
    26. Rand Protease: The Role of Calcium-Binding Site on Stability with Mutagenesis and The Effectiveness on Leather Dehairing Sains Malaysiana · 2023
    27. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002 · 146 citations
    28. The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles European Journal of Cell Biology · 2004 · 51 citations
    29. The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss Scientific Reports · 2017 · 19 citations
    30. Matrix-Degrading Type II Transmembrane Serine Protease Matriptase: Its Role in Cancer Development and Malignancy 2006 · 12 citations