38 citations,
June 2015 in “Expert Opinion on Therapeutic Targets” Blocking the prolactin receptor might help treat various diseases, but more research is needed.
30 citations,
July 2017 in “BioEssays” Activating NRF2 might help treat hair disorders by improving antioxidant defenses.
30 citations,
October 2016 in “Current research in translational medicine” Hair follicles on the scalp interact with and respond to the nervous system, influencing their own behavior and growth.
20 citations,
July 2015 in “Journal der Deutschen Dermatologischen Gesellschaft” Green tea may help with skin health and protect against UV damage, but more research is needed to confirm its safety and effectiveness.
19 citations,
September 2019 in “EMBO molecular medicine” Blocking TSLP reduces skin inflammation and cell overgrowth in psoriasis.
15 citations,
April 2017 in “Cell Stem Cell” Some brain cancer cells avoid immune system detection, and certain treatments could target this to slow their growth; also, certain fat cell precursors help regenerate hair and skin after injury.
11 citations,
February 2016 in “Current Medicinal Chemistry” New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.
10 citations,
May 2019 in “International Journal of Environmental Research and Public Health” Finasteride may cause kidney damage.
9 citations,
July 2020 in “Experimental Dermatology” Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.
8 citations,
January 1996 in “Springer eBooks” Male pattern baldness may be caused by factors like poor blood circulation, scalp tension, stress, and hormonal imbalances, but the exact causes are still unclear.
6 citations,
December 2020 in “Dermatological reviews” COVID-19 may worsen with androgens; anti-androgen drugs could help.
1 citations,
November 2015 in “Indian Journal of Clinical Biochemistry” The conference presented findings on how vitamin D levels, genetic factors, and lifestyle choices like smoking and yoga affect various health conditions and diseases.
1 citations,
January 2013 in “Springer eBooks” Cosmeceuticals may benefit skin health but need more research for efficacy and safety confirmation.
December 2023 in “Frontiers in endocrinology” Excess androgens may cause PCOS, not just be a symptom.
April 2015 in “Andrology” HNG may help prevent the negative effects of chemotherapy on sperm production and white blood cell counts.
15 citations,
June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” Mice with extra human KLK14 had hair and skin problems, including weaker cell bonds and inflammation, linked to Netherton syndrome.
November 2023 in “Journal of plant nutrition and soil science” Boron deficiency in maize affects leaf boron levels and nutrient uptake differently depending on root hair presence and soil type.
160 citations,
April 2014 in “Drug discovery today” Melatonin helps regulate sleep and may aid in treating various health issues.
44 citations,
September 2020 in “International Journal of Molecular Sciences” New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.
37 citations,
February 2005 in “Journal of Investigative Dermatology” In this study, overexpression of spermidine/spermine N1-acetyltransferase (SSAT) in transgenic mice led to increased putrescine levels, causing permanent hair loss and skin abnormalities such as dermal cysts and epidermal utriculi due to disturbed keratinocyte differentiation. This was characterized by altered expression of cytokeratins and filaggrin. The study found that reducing putrescine levels with DFMO treatment could alleviate these skin changes and promote hair regrowth, highlighting the importance of proper polyamine metabolism regulation for normal keratinocyte differentiation and hair follicle function. These findings had potential implications for understanding skin disorders and hair growth.
8 citations,
October 2021 in “Microbiology spectrum” Researchers identified five new potential targets for leishmaniasis treatment, suggesting repurposing existing drugs could be effective.
January 2024 in “Animals” SP1 promotes and KROX20 inhibits hair cell growth by affecting the CUX1 gene.
276 citations,
April 2003 in “Molecular endocrinology” Vitamin D is important for bones, hair, blood pressure, and breast development.
107 citations,
March 2014 in “BoneKEy Reports” Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.
68 citations,
January 2022 in “International Journal of Molecular Sciences” PCOS management includes lifestyle changes and medications, with ongoing research into repurposed drugs for better treatment options.
60 citations,
July 2014 in “Autophagy” The protein FLCN is involved in cellular cleanup and is regulated by ULK1.
7 citations,
December 2021 in “Pharmaceutics” Natural products like plant extracts can help promote hair growth and could be used to treat hair loss.
6 citations,
October 2020 in “Frontiers in cell and developmental biology” WWOX deficiency in mice causes skin and fat tissue problems due to disrupted cell survival signals.
6 citations,
January 2015 in “Evidence-based Complementary and Alternative Medicine” Saw palmetto extract may help treat brain tumors by blocking a specific growth signal and blood vessel formation.
1 citations,
November 2022 in “Animals” The research found specific genes and pathways that control fur development and color in young American minks.