Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study suggests that estrogen in contraceptive therapy may affect hair growth, potentially correcting hair loss under certain hormonal conditions; however, applying these findings to humans should be done cautiously.

This study found that patients with androgenic alopecia had altered neuroactive steroid levels and depression symptoms after stopping finasteride treatment, suggesting lingering neuropsychiatric effects.

In this study, researchers found that finasteride inhibits progesterone synthesis by blocking cholesterol side-chain cleavage in mouse-derived MA-10 Leydig cells, but this effect may not be evident in human or rat cells.

This study found that an 8-month treatment with a low-dose oral contraceptive significantly reduced testosterone levels and hair growth in women with polycystic ovary syndrome and hirsutism, with minimal side effects.

Lowering 3α,5α-THP in the hippocampus increases anxiety and depression in proestrous rats.

This article reviews pathologic mechanisms causing hair changes in women on hormonal contraceptives or pregnant and reports no new study results; hormonal effects on the hair cycle stages are suggested.

This article reviews the skin changes that can occur with hormonal contraceptive use and highlights various mechanisms and potential treatment strategies but reports no new clinical results.

In this study, two different estroprogestin treatments significantly improved skin conditions and decreased androgen levels in hyperandrogenic women, with EE/DRSP showing more pronounced hormonal changes and skin improvements compared to EE/CMA.

This study in female beagle dogs found that long-term exposure to oral contraceptive steroids resulted in significant reproductive and mammary gland changes, with the relevance to human tumor risk remaining uncertain.

In this study, Neogynon was found to be 100% effective as a contraceptive, with no observed failures in 3129 cycles among 184 women, while side effects included changes in endometrial patterns and some central nervous system effects.

In this study, pregnenolone was found to dose-dependently reduce L-DOPA-induced dyskinesias in a rat model of Parkinson's disease, suggesting its potential as a therapeutic target for these dyskinesias.

This study reported that bimatoprost significantly increased hair growth in rat vibrissa follicles by enhancing dermal papilla cell proliferation and upregulating cell cycle proteins like CDK2, Cyclin E, and β-catenin.

This study found that administering a supraphysiological dose of testosterone to female rats significantly reduced estrogen and progesterone levels, disrupted sex steroid receptor expression, and interfered with the embryonic implantation window, indicating potential implications for androgen-related endometrial conditions.

This study found that neurosteroids can reorganize GABA A receptors in mice, mimicking ovarian cycle changes, with the process being mediated by neurosteroid levels rather than direct hormone receptor activation.

This review discusses how neurosteroids acting on GABAA receptors may influence behavior and explores the potential for developing selective modulators for treating psychiatric disorders, but reports no new clinical results.

This study found that long-term GnRH agonist administration in premenopausal women with polycystic ovarian disease resulted in persistent suppression of ovarian steroid secretion, while adrenal steroid levels remained unchanged.

This study found that progesterone can increase glycine release in rat brainstem neurons through its conversion to allopregnanolone, which modulates presynaptic GABA receptor activity.

This study found that progesterone enhances the survival of newborn neurons in the hippocampus of adult male mice, which is associated with improved spatial learning and memory.

This review discusses developments in oral contraceptives, highlighting improved individualization, reduced side effects, and enhanced suitability for various women's health needs, but it reports no new clinical results.

Prostaglandin helps regenerate hair follicles after radiation damage.

The document concludes that a compound with potential for treating prostate cancer and hair loss was successfully made and its detailed structure was confirmed.

This study found that certain steroidal compounds, especially 10a–10c, demonstrated strong antiandrogenic activity by binding to the androgen receptor and reducing prostate weight in a hamster model.

This review discusses the roles of androgens in female mammals, focusing on how androgen receptor activity in pig reproductive organs may influence ovulation rate and litter size, but reports no new experimental results.

Different drugs are used to manage breeding, prevent or end pregnancy, and treat reproductive issues in dogs and cats.

This study suggests that the neurosteroid allopregnanolone may play a crucial role in how ethanol affects neurons related to alcohol addiction vulnerability.

5α-reduced progestogens may reduce mood issues and brain damage linked to HIV-1 Tat.

This study found that changes in the brain concentrations of neuroactive steroids during pregnancy are linked to increased Y 1 receptor gene expression in the medial amygdala of transgenic mice.

This review discusses the roles of prostaglandins in hair loss and highlights their potential as targets for new alopecia treatments, but reports no new clinical findings.

In this study, prolonged high-dose steroid treatment in rats caused several pathological changes, some of which regressed, particularly improvements in mammary gland tumors and pituitary-related symptoms, after stopping treatment.

This study found that feeding norethindrone acetate to albino rats over two years caused various dose-related health effects, such as growth retardation and liver changes, but did not increase overall tumor incidence.