This study reported that clascoterone cream reduced inflammatory and noninflammatory acne lesions in a trial with 1440 white males and non-pregnant females, showing it was well tolerated in these participants.
This presentation suggests that the activation of TRPV3 channels by fruit acids and carvacrol contributes to exfoliation and may underlie the skin-resurfacing effects of chemical peels.
6 citations
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February 2023 in “Journal of nanobiotechnology” In this study, HA-P5, a nanoparticle derived from peptide and polysaccharide conjugation, effectively reduced acne lesions and sebum production by inhibiting specific receptors in cells, without triggering unfavorable reactions compared to a commercial inhibitor, highlighting HA-P5's potential as a novel acne treatment.
37 citations
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January 2011 in “Annals of Dermatology” In this study, photodynamic therapy significantly reduced inflammatory acne lesions and sebum secretion, possibly by inducing apoptosis in sebaceous glands and down-regulating TLR-2 and TLR-4 expression.
7 citations
,
December 2019 in “American Journal of Clinical Dermatology” This review discusses the potential efficacy of topical antiandrogen therapies for treating androgenetic alopecia and acne vulgaris, finding promising results but highlighting the need for more comprehensive studies.
August 2026 in “Clinical Cosmetic and Investigational Dermatology” In this study, combining Polynucleotides High Purification Technology with hyaluronic acid significantly reduced atrophic post-acne scar areas and improved Goodman-Baron scores in a majority of treated patients over six months, reaffirming the approach's beneficial effects in a real-world outpatient setting.
May 2024 in “Reactions weekly”
1 citations
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November 1996 in “Journal of Cutaneous Medicine and Surgery” Hormones, especially androgens, play a key role in causing acne, and treatments like hormone control pills and hormone-blocking medications can help.
January 2013 in “프로그램북(구 초록집)” This review discusses the efficacy and safety of cyclosporine, methotrexate, and acitretin for managing psoriasis and reports no new clinical results; cyclosporine showed a rapid onset for severe psoriasis, methotrexate highlighted liver concerns, and acitretin was noted for its non-immunosuppressive benefits.
September 2022 in “Journal of the American Academy of Dermatology” The serum reduces acne and improves skin clarity.
September 2023 in “Journal of the American Academy of Dermatology” October 2018 in “Focus on surfactants”
22 citations
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March 2018 in “American Journal of Clinical Dermatology” This study found that hormonal antiandrogen acne treatment is associated with shorter antibiotic durations in women, suggesting early initiation may reduce overall antibiotic use.
35 citations
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March 2012 in “Journal of dermatological science” This observational study aims to more accurately detect and localize Propionibacterium acnes in acne lesions by combining multiple microbiological visualization techniques, but it does not present new results on their causality to acne.
February 1990 in “Journal of The American Academy of Dermatology” This review summarizes therapeutic advances reported in English-language literature from December 1987 to December 1988 and states no new clinical results.
4 citations
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September 2006 in “Prescriber” This review discusses acne pathogenesis and management, outlining key stages of the condition and summarizing various treatment options, but it reports no new clinical findings.
31 citations
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January 1981 in “Pharmacology & Therapeutics” In this study, 13-cis-5S*,8S*-epidioxy-5,8-dihydroretinoic acid was found to be significantly more cytotoxic to cancer cell lines than other retinoic acid analogs evaluated.
5 citations
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January 2014 in “Current Dermatology Reports” This review discusses various treatments for adult acne in women, including topical, systemic, and alternative therapies, and reports no new clinical results.
70 citations
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February 2019 in “The journal of immunology/The Journal of immunology” This study found that short-chain fatty acids produced by the skin microbe Propionibacterium acnes may drive inflammatory gene expression in sebocytes, potentially contributing to acne.
17 citations
,
June 2017 in “Journal of pharmaceutical sciences” This study found that adapalene-loaded nanospheres in a hyaluronic acid gel enhanced skin penetration and were nonirritant, making them potentially suitable for treating acne on oily skin.
117 citations
,
January 2003 in “Dermatology” This review discusses various treatments for moderate-to-severe acne, highlighting antibiotics, oral isotretinoin, and hormonal therapies, with a focus on resistance and emerging treatment options but reports no new clinical results.
5 citations
,
October 2016 in “Experimental Dermatology” This study found that activin A signaling is crucial for hair follicle neogenesis in human dermal papilla 3D cultures combined with mouse epidermal cells.
1 citations
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September 2025 in “Journal of Cosmetic Dermatology” This study introduces the "skinspan" framework to promote skin longevity through sun protection, topical retinoids, and antioxidants as first-line care. It suggests lasers and emerging therapies as additional options but emphasizes the need for more randomized controlled trials to solidify the evidence base.
1 citations
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November 1999 in “Hautarzt” Finasteride is not expected to be effective for treating Acne vulgaris.
85 citations
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April 2012 in “PLOS ONE” This study found that valproic acid promoted hair re-growth in C3H mice by activating the Wnt/β-catenin pathway, suggesting its potential as a treatment for alopecia.
January 2019 in “Springer eBooks” Acne can appear or persist in adulthood due to hormonal changes, external factors, or substance use, and requires appropriate treatment.
November 2024 in “American Journal of Biomedical Science & Research” This abstract does not provide study results but outlines that acne is influenced by factors like androgens, sebum production, abnormal keratinization, and inflammatory reactions involving lymphocytes, macrophages, and neutrophils.
April 2016 in “Journal of The American Academy of Dermatology” Daylight photodynamic therapy is effective and well-tolerated for treating actinic keratoses with minimal side effects.
2 citations
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May 1984 in “Current Problems in Pediatrics” This article provides an overview of acne management for pediatricians and emphasizes patient education but reports no new clinical findings.
1 citations
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September 2021 in “Dermatologic Therapy” In this observational study, AC5 reduced hair loss in 89% of subjects with mild androgenic alopecia, and was well tolerated and appreciated by most participants.