Skinspan: A Holistic Roadmap for Extending Skin Longevity With Evidence-Based Interventions

    September 2025 in “ Journal of Cosmetic Dermatology ”
    Elizabeth Kream, Sabrina G. Fabi, Monica Boen
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    Studysummary This study introduces the "skinspan" framework to promote skin longevity through sun protection, topical retinoids, and antioxidants as first-line care. It suggests lasers and emerging therapies as additional options but emphasizes the need for more randomized controlled trials to solidify the evidence base. Our plain-language summary of this paper — not a Tressless recommendation.
    The document introduces "skinspan," a concept focused on extending the period of youthful, healthy skin through evidence-based interventions. It identifies intrinsic and extrinsic factors contributing to skin aging and suggests interventions like photoprotection, smoking cessation, and a healthy lifestyle to support skin health. Medical interventions such as retinoids, vitamin C, and stem cell therapies are also discussed. The paper outlines a roadmap with first-line strategies like sun protection and antioxidants, second-line interventions like laser treatments, and emerging third-line therapies such as stem cell-based treatments. It emphasizes the importance of combining lifestyle and medical strategies to preserve skin health and calls for more randomized clinical trials to support new therapies.
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