Skinspan: A Holistic Roadmap for Extending Skin Longevity With Evidence-Based Interventions

The document introduces "skinspan," a concept focused on extending the period of youthful, healthy skin through evidence-based interventions. It identifies intrinsic and extrinsic factors contributing to skin aging and suggests interventions like photoprotection, smoking cessation, and a healthy lifestyle to support skin health. Medical interventions such as retinoids, vitamin C, and stem cell therapies are also discussed. The paper outlines a roadmap with first-line strategies like sun protection and antioxidants, second-line interventions like laser treatments, and emerging third-line therapies such as stem cell-based treatments. It emphasizes the importance of combining lifestyle and medical strategies to preserve skin health and calls for more randomized clinical trials to support new therapies.