TLDR The framework suggests sun protection, retinoids, and antioxidants to improve skin longevity.
The skinspan framework provides a comprehensive, evidence-based strategy for enhancing skin longevity, emphasizing prevention, continuous care, and patient education beyond mere aesthetic treatments. The recommended first-line interventions include sun protection, topical retinoids, and antioxidants. Second-line options involve procedures like laser and energy-based devices. Emerging therapies such as stem cell treatments, sirtuins, nicotinamide, and natural SIRT activators are suggested as third-line adjuncts. The framework highlights the necessity for more randomized controlled trials to bolster the evidence supporting these interventions.
June 2025 in “International Journal of Dermatology” Exosomes could transform skin treatments but face technical and regulatory hurdles.
21 citations
,
November 2023 in “International Journal of Molecular Sciences” Melatonin helps reduce aging signs in human eyelid skin.
February 2023 in “Journal of Drugs in Dermatology” Melatonin may help improve hair growth in people with certain types of hair loss.
32 citations
,
January 2022 in “International Journal of Molecular Sciences” Melatonin, a hormone, can help protect skin from aging by reducing stress, inflammation, and damage, and may also help treat hair loss in women.
88 citations
,
June 2019 in “Cell reports” Certain small molecules can promote hair growth by activating a cellular cleanup process called autophagy.
221 citations
,
July 2012 in “Proceedings of the National Academy of Sciences of the United States of America” BMAL1 controls skin cell growth and UV damage risk, peaking at night.
December 2025 in “Pharmaceutics” Personalized skin rejuvenation using genomics shows promise but needs more research.
November 2025 in “Dermato” The skin microbiome is crucial for skin health and new treatments like probiotics can improve skin conditions.
15 citations
,
April 2022 in “Biointerface Research in Applied Chemistry” Medicinal plants may be an effective alternative for treating acne.
26 citations
,
October 2020 in “Biomedicines” Bioengineered skin models help reduce animal testing and advance research in cosmetics and skin disease.
March 2024 in “Antioxidants” Excessive blue light harms eye cells and disrupts sleep patterns.
