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A 37-year-old male with severe skin and internal issues has a rare inherited skin condition called dystrophic epidermolysis bullosa.

Skin health and repair depend on the signals between skin stem cells and their surrounding cells.

Caffeine intake during pregnancy and lactation can cause skin lesions in mother rats and their babies, not linked to cortisol levels.

Mast cells play a significant role in hair loss conditions like male pattern hair loss and alopecia areata.

Herpes gestationis is linked to certain antigens, atopic eczema affects T cell populations and may be eased by breastfeeding, higher doses of anti-androgen treatment can improve androgenic alopecia, topical minoxidil increases hair thickness, long-term methotrexate therapy can cause liver fibrosis in psoriasis patients, and Lichen Sclerosus et Atrophicus patients aren't at higher risk for autoimmune disorders.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

PCOS is a complex condition with major health impacts, needing more research for better diagnosis and treatment.

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

The document concludes that understanding hair structure is key to diagnosing hair abnormalities and recommends gentle hair care for management.

Giving a special protein to dogs with a certain genetic disease improved their symptoms but didn't help with hair growth.

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.

Finasteride may cause slight depression and anxiety.

Mutant CDP/Cux protein causes hair defects and reduced male fertility in mice.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

TCDD speeds up skin barrier formation by increasing certain gene expressions.

PCOS starts in adolescence with hormonal issues, leading to adult health problems, and early treatment is crucial.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

PCOS in teens is hard to diagnose, linked to genetics and lifestyle, and managed with weight loss and medication.

Vitamin D3 affects cell differentiation in specific skin areas.

The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.