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This review summarizes the potential therapeutic applications of stem cells in dermatology, emphasizing their role in restorative and regenerative treatments through injections, topical applications, and scaffolds, supported by advancements in laboratory processes and quality control.

This study found that human embryonic stem cell-derived mesenchymal stem cells promote hair growth and enhance the transition from the telogen phase to the anagen phase in mice, especially under hypoxic conditions.

This study found that incorporating cell-adhesive ligands into 3D peptide hydrogels supports the survival and osteogenic differentiation of human amniotic mesenchymal stem cells.

This study found that combining a human acellular amniotic membrane with iPSC-derived epithelial stem cells effectively repaired skin defects and promoted hair follicle formation in nude mice.

This review outlines the potential of using human pluripotent stem cells for hair follicle bioengineering, detailing current HF morphogenesis and cycling knowledge, various cell sources, and strategies using iPSCs, while discussing the challenges and prospects for therapeutic use in addressing hair loss.

This study developed a stable cell line model to evaluate hair differentiation activity, offering a new tool for screening drugs that promote hair growth using mouse iPS cell-derived systems.

This review highlights that iPSC-derived artificial platelets offer a promising alternative to platelet-rich plasma for regenerative medicine, with standardized manufacturing and reproducible pharmacological properties, addressing variability issues associated with donor-derived platelets and showing therapeutic potential in preclinical models of osteoarthritis.

This study reported that human induced pluripotent stem cell-derived skin organoids, used to model epidermolysis bullosa, have an epidermal-dermal junction largely lacking type VII collagen, which is important for skin structure.

This study found that human hair follicle-derived mesenchymal stem cells effectively maintained human embryonic stem cells in an undifferentiated state, comparable to mouse embryonic fibroblasts under standard conditions.

In this study, researchers found that correcting the HGPS mutation with Adenine base editing partially rescued accelerated skin cell differentiation and reduced cell death in patient-derived stem cells.

This study found that fetal canine hair follicle-derived stem cells exhibited pluripotency markers, suggesting potential for therapeutic applications in hair and skin repair.

This review discusses recent research on melanocyte stem cells and explores the differences between mouse and human skin, but it reports no new clinical results.

The researchers reported that iPSCs derived from Sendai virus reprogrammed blood cells can mature into functional keratinocytes for up to 60 days, potentially offering new approaches for DEB treatment.

Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.

This review discusses the advancements and challenges in developing in vitro human skin models incorporating components like vasculature for drug testing and disease research, but reports no new clinical results.

This study found that forming spheroids using silicone micro-wells improved the viability and neural differentiation potential of human adipose-derived stem cells after thawing.

This study demonstrated that hair follicle cells can be induced to differentiate into cardiomyocyte-like cells in vitro, exhibiting characteristics and spontaneous beating typical of cardiac muscle, without genetic modification.

This article reviews current strategies and advancements in regenerating skin appendages and sensory nerves in tissue-engineered skin, highlighting the challenge of restoring skin sensations like pain, temperature, and touch to improve patients’ quality of life.

This review discusses various stem cell types, methods of obtaining them, their applications, and the potential use of exosomes, but reports no new clinical results.

In this perspective, recent advances in regenerative medicine, including bioartificial substitutes and engineered in vitro platforms, are reviewed for their potential to restore human hair follicles, highlighting new technologies like 3D printing, hair-on-a-chip models, and stem cell-derived organoids.

In this study, researchers differentiated human induced pluripotent stem cells into dermal papilla-like cells and observed gene expression dynamics during five stages of dermal differentiation, demonstrating the potential of these cells to interact with epidermal cells in functional assays.

This study demonstrated that a 3D air–liquid culture system using Wnt-CM-treated cells can induce hair regeneration in nude mice and may facilitate large-scale preparation for hair loss treatment.

This study validated a protocol for inducing surface ectoderm differentiation from human induced pluripotent stem cells and highlighted the role of TGFβ signaling pathways in this process.

This review discusses the potential roles of calcium in the regulation of pluripotent and tissue-specific stem cells but reports no new experimental results, highlighting areas for future research.

This review explores various theories of colorectal cancer stem cell biology and highlights the need for better identification and targeting of these cells to advance treatment strategies, but reports no new clinical findings.

In this study, hair follicle stem cells from ND-GFP transgenic mice were observed to be pluripotent, effectively repairing peripheral nerve and spinal cord injuries in mouse models.

In this study, researchers used a human skin organoid model to show that solar UV exposure damages hair follicles and skin, while exosomes from mesenchymal stem cells reduced inflammation and supported hair follicle regeneration.

In this study, researchers successfully generated hair follicle organoids using human induced pluripotent stem cells (hiPSCs) with collagen I as a microenvironment, demonstrating potential applications in hair regeneration, though fully human organoids require additional approaches.

This study observed that tissue-engineered skin, using VEGF165 gene-modified cells embedded in astragalus polysaccharide-containing 3D printed scaffolds, enhanced early vascularization, and collagen and hair follicle regeneration, leading to improved skin repair in nude mice with full skin defects.

This study demonstrated that dermal papilla cells were more efficiently reprogrammed into induced pluripotent stem cells than dermal fibroblasts, suggesting their potential as a source for iPS cells.