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research Bexxar, iodine I 131 tositumomab, Effective in Long Term Follow-up of Non-Hodgkin's Lymphoma
This study found that 86% of patients with follicular non-Hodgkin's lymphoma were alive and nearly two-thirds remained in complete remission eight years after initial treatment with the radioimmunotherapy drug Bexxar.
research Molecular and Functional Characterization of Clonogenic Human Thymic Epithelial Cells
This study demonstrated that the human thymus contains clonogenic thymic epithelial cells capable of self-renewal and maintaining a thymic phenotype in a specific culture system.
research Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization
In this study, autologous platelet-rich plasma improved skin wound healing in mice, associated with reduced inflammation and enhanced angiogenesis and re-epithelialization, but the underlying regulatory mechanism requires further investigation.
research Human placental mesenchymal stromal cell‐derived exosome‐enriched extracellular vesicles for chronic cutaneous graft‐versus‐host disease: A case report
This case report observed that treatment with human placental mesenchymal stromal cell-derived exosome-enriched extracellular vesicles may improve symptoms of chronic cutaneous graft-versus-host disease, including hyperpigmentation and skin ulcers, in a patient resistant to conventional therapies.
research As a carrier–transporter for hair follicle reconstitution, platelet-rich plasma promotes proliferation and induction of mouse dermal papilla cells
This study found that 5% activated platelet-rich plasma significantly improved cell proliferation and hair-inductive ability of dermal papilla cells in vitro, and promoted hair follicle formation in mice.
research 307 Phenotypic-genotypic expansion of plectinopathy in a patient with muscular dystrophy and immune-mediated myasthenia gravis
In this case study, a 26-year-old female with PLEC mutations and features of muscular dystrophy and myasthenia gravis showed significant improvement in symptoms following steroid treatment.
research Trichoblastic Carcinoma (“Malignant Trichoblastoma”) with Lymphatic and Hematogenous Metastases
Long-standing benign tumors can become cancerous, especially in people with weakened immune systems.
research LB1606 Retainability of pluripotency and viability of multilineage-differentiating stress enduring (Muse) cells after repeated cryopreservation.
This study found that Muse cells retained their pluripotency and ability to differentiate into various cell types even after being cryopreserved multiple times.
research Photothermal Biomodulated Platelet-rich Plasma Improves Preservation of Hair Grafts and Extends Their Viability
In this proof-of-concept study, researchers found that hair grafts preserved in preconditioned autologous platelet-rich plasma with photothermal biostimulation and phosphate-buffered saline remained viable for eight hours before transplantation, outperforming saline solution and Ringer's lactate by two hours.
research 858 IPSC derived keratinocyte differentiation from reprogrammed blood cells
The researchers reported that iPSCs derived from Sendai virus reprogrammed blood cells can mature into functional keratinocytes for up to 60 days, potentially offering new approaches for DEB treatment.
research THE USE OF PLATELET-RICH PLASMA TO IMPROVE IN VITRO EMBRYO PRODUCTION AND IMPLANTATION RATE IN MAMMALS
This review highlights the potential of platelet-rich plasma as a therapeutic tool in animals, noting its mixed efficacy and promising applications in areas like reproduction, but reports no new clinical results.
research Breast cancer resistance protein identifies clonogenic keratinocytes in human interfollicular epidermis
This study indicates that ABCG2 expression identifies interfollicular keratinocyte progenitor cells in human epidermis and suggests it could help enrich these stem cells for research and treatment.
research Perifollicular Melanocyte Regeneration in Bullous Pemphigoid
This case report describes perifollicular melanocyte regeneration in the affected skin of a patient with bullous pemphigoid, highlighting an underreported aspect of the condition in skin of color patients, and emphasizing the need for increased awareness and earlier diagnosis in this demographic.
research Protein kinase Akt2/PKBβ is involved in blastomere proliferation of preimplantation mouse embryos
In this study, Akt2 and the oncogenic protein Tcl1 were found to be essential for early blastomere proliferation and embryo development in preimplantation mouse embryos.
research Tratamiento ortobiológico con plasma rico en plaquetas. Revisión sistemática y clasificación de la evidencia
This review examines platelet-rich plasma therapy for musculoskeletal and soft tissue injuries and reports no firm evidence supporting its routine use due to poor study design and inconsistent results.
research Use of platelet‐rich plasma in treating a wound infection following tophi rupture: A case report
This case report describes successful wound healing in a patient with chronic gout and tophaceous ulcers following platelet-rich plasma therapy, highlighting its potential effectiveness in treating non-healing wounds.
research A phase 1b study of chemo-immunotherapy with pegylated liposomal doxorubicin and Pembrolizumab in estrogen receptor positive metastatic breast cancer
In this phase 1B study, patients with ER-positive/HER2-negative metastatic breast cancer receiving combined pegylated liposomal doxorubicin and pembrolizumab had a disease control rate of 67% with responses lasting a median of 11 months; the treatment was well tolerated and showed potential for extended use.
research 454 Modeling epidermolysis bullosa simplex with cardiomyopathy using KLHL24-mutant pluripotent stem cells.
KLHL24-mutant stem cells help understand skin and heart disease.
research Human follicular stem cells: their presence in plucked hair and follicular cell culture
This study found CK19/Bcl-2-positive and Bax-negative cells in hair follicle cultures from plucked hairs, supporting their potential identification as follicular stem cells located in the bulge area.
research 301 The Spectrum of PLEC Sequence Variants and Related Plectinopathies Including Novel Association with Epidermolysis Bullosa Pruriginosa
This study identified 15 Iranian patients with PLEC variants linked to various plectinopathies and highlighted a novel association between a homozygous nonsense variant in PLEC and a rare combination of disorders including EB pruriginosa, muscular dystrophy, and congenital myasthenic syndrome.
research Platelet-rich plasma therapy: key infection prevention practices and strategies for safety risk reduction
This article discusses developing a standardized operating procedure for PRP administration to align with infection prevention regulatory standards and reports no new clinical results.
research Blood Donors on Medication – an Approach to Minimize Drug Burden for Recipients of Blood Products and to Limit Deferral of Donors
This study concluded that blood donors on certain medications can donate blood products with less than 50 ml single-donor plasma for adult use without deferral, except for those taking specific medications like retinoids and genotoxic drugs.
research Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020
This review discusses the potential of platelet-rich plasma applications in regenerative medicine and explores recent progress and challenges in translating non-clinical PRP findings into human treatments, but reports no new clinical results.
research 219 Clinical and immunological impact of booster immunization with recombinant mRNA vaccines for SARS-CoV-2 in patients with pemphigus and bullous pemphigoid
This study found that mRNA booster vaccinations for SARS-CoV-2 increased protective antibodies without worsening autoimmune disease activity in patients with pemphigus and bullous pemphigoid.
research 311 Single-cell transcriptomics reveals distinct molecular programs in folliculotropic mycosis fungoides
This study revealed distinct cellular and transcriptomic differences among various subtypes of cutaneous T-cell lymphoma, particularly highlighting characteristics unique to folliculotropic mycosis fungoides.
research 0040 Machine learning algorithms as tools for identifying predictive autoantibody biomarkers in pemphigus vulgaris
This study found that both desmoglein-specific and non-desmoglein autoantibodies may play active roles in Pemphigus vulgaris pathogenesis, with HLA genetics influencing autoimmune specificity.
research What's new in the pathogeneses and triggering factors of bullous pemphigoid
This review discusses recent findings on the mechanisms driving bullous pemphigoid, highlighting epitope spreading and the roles of regulatory T cells, and reports no new experimental results.
research PLCD1 and Pilar Cysts
This study identified a high-risk allele in the PLCD1 gene associated with hereditary trichilemmal cyst formation, proposing a monoallelic two-hit mechanism as the underlying genetic pathogenesis.
research PROSPECT OF UTILIZING EXPIRED HOMOLOGOUS PLATELET CONCENTRATES AS AN ALTERNATIVE SOURCE OF GROWTH FACTORS AND CYTOKINES IN CLINICAL SETUP FOR BETTER WOUND CARE AND HEALING
This study found that human platelet lysate, prepared from expired platelet concentrate, maintained stable growth factor levels for up to six months and improved healing in second-degree burn wounds compared to standard silver sulfadiazine treatment at three weeks.