Retainability of Pluripotency and Viability of Multilineage-Differentiating Stress Enduring (Muse) Cells After Repeated Cryopreservation

    August 2018 in “ Journal of Investigative Dermatology ”
    F. Motoe, Takeshi Yamauchi, Kenshi Yamasaki, Setsuya Aiba
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    TLDR Muse cells keep their special features and can become different cell types even after being frozen and thawed three times.
    The document from September 2018 studied the impact of repeated cryopreservation on Muse cells, a type of pluripotent stem cell. The study demonstrated that Muse cells retained their pluripotency after being cryopreserved up to three times, as shown by positive alkaline phosphatase staining and the expression of key pluripotency genes (Nanog, Oct4, and Sox2). Furthermore, these cells preserved their ability to differentiate into various cell lineages, including neurons, chondrocytes, and hepatocytes. These findings support the potential of Muse cells for use in personalized regenerative medicine, due to their minimal invasive collection method from skin tissues and their resilience to multiple cryopreservations.
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