Orthobiological Treatment with Platelet-Rich Plasma: Systematic Review and Evidence Classification

The systematic review of platelet-rich plasma (PRP) treatment for musculoskeletal and soft tissue injuries in various medical fields found that while 75% of studies had a high level of evidence, the overall methodological quality was poor, with 50% of studies highlighting design deficiencies and inconsistent results. The recommendation grades were mostly good or favorable, with 40.9% grade A, 50% grade B, and 9% grade C. However, due to contradictory findings and low-quality study designs, there was no strong evidence to support the routine use of PRP. The study concluded that more rigorous and standardized research is needed for PRP to be widely accepted as an orthobiological agent.