31 citations
,
September 2013 in “Stem Cells” This study suggests that canonical BMP signaling, particularly involving Smad1 and Smad5, plays a critical role in hair follicle stem cell regulation and hair morphogenesis, with distinct roles from pSmad8.
18 citations
,
April 2016 in “Toxicological Research” This study found that lavender oil significantly promoted hair growth in female C57BL/6 mice by increasing hair follicle number, depth, and dermal thickness, while reducing mast cell numbers.
11 citations
,
May 2022 in “Chinese medicine” This study found that Alpinetin, applied topically in C57BL/6J mice, promoted hair regeneration by activating hair follicle stem cells through Wnt signaling, extending the anagen phase and increasing hair shaft length, with no cytotoxicity observed in keratinocytes and fibroblasts.
10 citations
,
January 2014 in “Genetics and Molecular Research” This study observed that primary hair follicles in Liaoning Cashmere goats had broader hair bulb widths compared to secondary follicles, with the difference diminishing during the anagen phase of hair follicle development.
5 citations
,
June 2023 in “BMC genomics” This study found that a specific genetic mutation in the Fgf5 gene may contribute to the long-hair trait in Angora rabbits by reducing the binding capacity of the FGF5 protein.
4 citations
,
February 2021 in “Journal of Pharmaceutical Sciences” This study suggests that the developed PBPK model effectively predicts pharmacokinetic and pharmacodynamic profiles of topical finasteride and minoxidil on the scalp, indicating potential broader applicability for other formulations.
1 citations
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October 2025 in “Nature Communications” This study observed that, in mouse ear epidermal stem cells, a cell-autonomous size control mechanism involving the RB pathway dictates S phase entry timing based on cell size, despite external environmental variations affecting growth rates.
This pilot study found that a high fat lard diet may protect against fibrosis and affect the hair follicle cycle in a mouse model of systemic sclerosis, unlike a high fat coconut oil diet.
32 citations
,
December 1969 in “The Lancet” This study found a significant shift to the telogen phase in the hair growth of children with classical marasmus compared to normal children, suggesting a connection to the chronicity of the condition.
10 citations
,
June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified FP-1 as a highly specific extracellular matrix protein in follicular papilla cells, which may play a role in hair growth regulation during specific hair cycle phases.
June 2026 in “The Journal of the Kyushu Dental Society” This study reviews the development of a mouse model using pyroxylin to induce localized hair growth and shorten the hair cycle's resting phase, suggesting it as a platform for evaluating hair growth treatments, though further research is needed for human application.
November 2025 in “Journal of Investigative Dermatology” NUL-5 may boost hair growth by improving hair follicle health and structure.
April 2018 in “Journal of Investigative Dermatology” This study identified the osteopontin-derived peptide, FOL-005, as a potential inhibitor of unwanted human hair growth by promoting catagen development without reducing stem cell numbers or showing toxicity.
June 2024 in “International Journal of Pharmaceutical Quality Assurance” This study established a new reverse-phase high-performance liquid chromatography method to accurately and precisely quantify silodosin and dutasteride in mixtures, meeting International Council of Harmonization validation criteria for stability, sensitivity, and recovery.
90 citations
,
January 2002 in “Dermatology” This study describes the kenogen phase, where hair follicles rest after shedding, and finds its duration and frequency are greater in individuals with androgenetic alopecia, potentially contributing to baldness.
71 citations
,
January 1998 in “Pathobiology” This review discusses the use of animal models to study alopecia areata and reports no new experimental results, emphasizing the potential for these models to explore the disease's genetics and treatment.
1 citations
,
December 2009 in “Asian Journal of Research in Chemistry” This study developed and validated ultraviolet spectrophotometric and reversed phase high performance liquid chromatographic methods for simultaneously estimating Tamsulosin and Finasteride in tablet form, showing statistical validation and effectiveness in pharmaceutical analysis.
20 citations
,
December 1997 in “Clinical Endocrinology” This article discusses the potential beneficial effect of spironolactone on androgenic alopecia but provides no new clinical findings.
1 citations
,
September 2023 in “Journal of the American Academy of Dermatology” This study focused on baricitinib's effect on patients with severe alopecia areata, highlighting its efficacy for hair regrowth and its potential to improve health-related quality of life and psychological symptoms, as seen in two phase 3 trials.
3 citations
,
June 2017 in “International Journal of Radiation Biology” This review of murine studies reports that γ-rays affect hair follicle pigmentation in mice throughout the hair cycle, while effects on hair structure may be obscured by aging.
1 citations
,
June 2022 in “JAMA” This study found that oral baricitinib treatment led to hair regrowth in patients with alopecia areata, as observed in two phase 3 trials.
September 2025 in “Journal of the American Academy of Dermatology” Deuruxolitinib improves anxiety and depression in severe alopecia areata patients.
January 2024 in “Современные проблемы науки и образования (Modern Problems of Science and Education)” Miliacin helps extend the hair growth phase in mice with hair loss.
July 2025 in “JOURNAL OF CLINICAL AND BIOMEDICAL SCIENCES” This study describes a case in which a 24-year-old woman with PCOS symptoms, including irregular menstruation and excessive hair growth, showed significant improvement in androgen levels, menstrual regularity, and hair reduction after undergoing a nine-month Ayurvedic treatment plan with dietary and lifestyle modifications.
May 2019 in “Journal of clinical oncology” This Phase 1 study reported that topical application of BPM31543 was safe and well-tolerated in patients receiving taxane-based chemotherapy, with some experiencing less than 50% hair loss, suggesting potential efficacy in reducing chemotherapy-induced alopecia, although no maximum tolerated dose was identified.
119 citations
,
November 1969 in “Journal of Ultrastructure Research” Macrophages help break down collagen around hair follicles during hair growth.
5 citations
,
April 2022 in “Genes” In Angora rabbits, overexpression of miR-129-5p was found to induce apoptosis and inhibit proliferation of dermal papilla cells, highlighting its role in hair follicle development by targeting HOXC13.
4 citations
,
September 2022 in “Journal of The American Academy of Dermatology” This study examined phase 3 clinical trial data and found that baricitinib improves hair regrowth in adults with alopecia areata and significant scalp hair loss, with the response varying based on the severity of hair loss at the start of treatment.
Ashwagandha-derived nanoparticles can promote human hair growth.
September 1997 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” Anti-IL-1 treatments might help with certain types of hair loss in people with high inflammation.