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Cicatricial alopecia, a permanent hair loss condition, is mainly caused by damage to specific hair follicle stem cells and abnormal immune responses, with gene regulator PPAR-y and lipid metabolism disorders playing significant roles.

PPARγ is crucial for skin health but can have both beneficial and harmful effects.

TGFβ signaling prevents sebaceous gland cells from producing fats.

Prostaglandins and the enzyme AKR1C3 could play a role in skin cancer and hair loss, and further research is needed to understand these mechanisms.

Blocking EGFR in skin cells doesn't majorly increase inflammation markers.

Blocking cholesterol production may help control hair loss in Primary Cicatricial Alopecia by affecting key regulators.

GMG-43AC may help reduce unwanted hair growth and treat certain hair loss conditions.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

CBG may help with various medical conditions but needs more human research to confirm safety and effectiveness.

Frontal Fibrosing Alopecia might be an autoimmune disease.

Skin symptoms can indicate endocrine disorders and have various treatments.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Hormonal treatments are effective for severe or persistent acne and should be used with other acne therapies, considering potential side effects.

Substance P may worsen acne by increasing inflammation, but corticosteroids might help by reducing this effect.

New understanding of the causes of primary cicatricial alopecia has led to better diagnosis and potential new treatments.

The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.

Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.

Diagnose and manage CCCA with thorough history, exams, and labs; treat with anti-inflammatory agents, stress reduction, and stopping harmful hair practices.

Testing for CAG repeat polymorphism in the androgen receptor gene is not currently recommended for managing hypogonadism.

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

Lower lipin 1β in belly fat is linked to insulin resistance in people with polycystic ovary syndrome.

Isotretinoin improves severe acne without changing androgen or insulin levels but may increase body weight and triglycerides.