research Interactions of the Vitamin D Receptor with the Corepressor Hairless
Most Hairless gene mutations reduce its ability to work with the Vitamin D Receptor, which might explain a certain type of hair loss.
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research Alopecia Areata: A Review
Alopecia areata is an autoimmune hair loss condition treated with corticosteroids, and histologic confirmation is the best diagnosis method.
research Immunology of Alopecia Areata
Alopecia areata, a type of hair loss, is likely an autoimmune disease with a genetic link, but its exact cause is still unknown.
research A Patient With Combined Polycystic Ovary Syndrome And Autoimmune Polyglandular Syndrome Type 2
A woman was the first known case to have both polycystic ovary syndrome and autoimmune polyglandular syndrome type 2, suggesting a need to check for both conditions in similar patients.
research Anticytokine Therapy, Particularly Anti-IFN-γ, in Th1-Mediated Autoimmune Diseases
Blocking interferon-gamma might help treat various autoimmune diseases.
research Autoimmune Gastritis and Parietal Cell Reactivity in Two Children with Abnormal Intestinal Permeability
Children with autoimmune gastritis showed improved intestinal health over time and should be checked for other autoimmune conditions.
research T-Cell Reconstitution After Thymus Xenotransplantation Induces Hair Depigmentation and Loss
T-cell reconstitution after thymus transplantation can cause hair whitening and loss.
research Mutation in 5′ Upstream Region of GCHI Gene Causes Familial Dopa-Responsive Dystonia
A specific gene mutation is linked to a hereditary form of dystonia that responds well to certain medications.
research Abstracts
The document reports findings on genetic research, including ethical concerns about genome editing, improved diagnosis of mitochondrial mutations, solving inherited eye diseases, confirming gene roles in epilepsy, linking a gene to aneurysms, and identifying genes associated with age-related macular degeneration.
research Hashimoto Thyroiditis - A Comprehensive Review
Hashimoto thyroiditis is an autoimmune disease that can lead to an underactive thyroid and is treated with medication and sometimes diet changes or surgery.
research Small Molecule Inhibitors and Inflammatory Skin Diseases
New drugs targeting the JAK-STAT pathway show promise for treating inflammatory skin diseases.
research Patent Reports
New patents include innovations in skin and hair care, disease treatment, plant stress tolerance, and protein purification.
research Cutaneous Toxicities From Transplantation-Related Medications
Skin problems from transplant drugs are common and need careful management in organ transplant patients.
research Organic and Biogenic Nanocarriers as Bio-Friendly Systems for Bioactive Compounds Delivery: State-of-the-Art and Challenges
Organic and biogenic nanocarriers can improve drug delivery but face challenges like consistency and safety.
research Genetic Association of Complement Component 2 Polymorphism with Systemic Lupus Erythematosus
The A allele of the C2 gene increases the risk of lupus, while the G allele may protect against it.
research Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One
Adding a second method to PROTACs could improve cancer treatment.
research Combined Drug Triads for Synergistic Neuroprotection in Retinal Degeneration
Using three different drugs together may better treat eye diseases like glaucoma and macular degeneration.
research Editor's Evaluation: Involvement of ILC1-Like Innate Lymphocytes in Human Autoimmunity, Lessons from Alopecia Areata
ILC1-like cells can independently cause alopecia areata by affecting hair follicles.
research Host-Microbiome Interactions and Recent Progress in Understanding the Biology of Acne Vulgaris
Acne is linked to complex skin microbe interactions, and new findings suggest microbiome-based treatments could be effective.
research Induction of T Cell Exhaustion by JAK1/3 Inhibition in the Treatment of Alopecia Areata
Ifidancitinib, a JAK inhibitor, effectively regrows hair in mice with alopecia by tiring out harmful T cells.
research Study of the Thyroid Profile of Patients with Alopecia
People with hair loss conditions may also have thyroid disorders, but more research is needed to understand the connection.
research Genes and Immune Response in Alopecia Areata: Review of the Alopecia Areata Research Summit First Day Proceedings
Alopecia areata involves complex immune and genetic factors, with potential treatment targets identified, but more research is needed.
research Interleukin-15 Is a Hair Follicle Immune Privilege Guardian
Interleukin-15 can help hair growth and protect hair follicles.
research Case Report: Heterozygous Mutation in HTRA1 Causing Typical Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
A heterozygous mutation in HTRA1 can cause severe CARASIL symptoms.
research Genetics of Hidradenitis Suppurativa
Hidradenitis Suppurativa has genetic links, with certain gene mutations more common in patients and a third of cases having a family history.
research Life-Threatening Macrophage Activation Syndrome as the Initial Presentation of Systemic Lupus Erythematosus: A Case Report and Review of the Literature
Macrophage activation syndrome can be a deadly first sign of systemic lupus erythematosus.
research Abdominal Pain in a Young Woman With Systemic Lupus Erythematosus
A young woman with lupus was treated with hydroxychloroquine and prednisone.
research A Young Girl With Lupus, Recurrent Pericardial Effusion, And Cardiac Tamponade
Adding colchicine stopped the girl's recurring heart issues caused by lupus.
research Fine Mapping of the Human AR/EDA2R Locus in Androgenetic Alopecia
Genetic marker rs12558842 strongly linked to male hair loss.
research Connective Tissue Disorders
Different connective tissue disorders have unique symptoms and treatments, with varying outcomes and often require ongoing care from a specialist.