41 citations
,
March 2007 in “Steroids” This article reviews recent advances in the synthesis of oxasteroids and reports no new experimental results.
35 citations
,
May 2015 in “Thrombosis Research” This review synthesizes knowledge on Prostaglandin E2's role in platelet biology and suggests that targeting PGE2 pathways could lead to personalized antiplatelet therapy without affecting hemostasis, but it presents no new results.
32 citations
,
April 2006 in “The Journal of Urology” Using finasteride with TIP extends time off period for prostate cancer patients.
31 citations
,
July 2004 in “Molecular Medicine” This study found that mutant glucocorticoid receptors have defective transcriptional activity and dynamic motility issues in the nucleus, likely due to impaired interactions with nuclear molecules necessary for gene activation.
30 citations
,
June 2006 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, oral zinc sulphate was found to cause hair hypopigmentation and significantly inhibit eumelanogenesis in mice.
28 citations
,
January 2021 in “Parkinsonism & related disorders (Online)/Parkinsonism & related disorders” This article reviews skin disorders in Parkinson's disease, highlighting the potential of skin studies and stem cell research to advance understanding and treatment of the neurodegenerative disorder, without presenting new results.
27 citations
,
May 2015 in “Neuropharmacology” This study found that Dutasteride, a 5α-reductase inhibitor, demonstrated neuroprotective effects by preventing the MPTP-induced decline of dopaminergic markers in a Parkinson's disease mouse model.
26 citations
,
May 2014 in “BioEssays” This review discusses how neuroendocrine pathways influence keratin regulation in human skin and hair follicles and suggests these pathways as potential targets for new treatments of skin disorders, but reports no clinical results.
24 citations
,
January 2008 in “KARGER eBooks” This review discusses recent advances in understanding the pathogenesis of autoimmune alopecia areata and reports no new clinical results; it highlights potential for developing more effective treatments.
21 citations
,
February 2017 in “PLoS ONE” This study found that RhoA influences embryonic stem cell proliferation through the PKN1-cyclin D1 pathway in vitro, suggesting RhoA as a potential target for wound healing therapies.
20 citations
,
January 2017 in “Actas Dermo-Sifiliográficas” This review discusses recent therapeutic advances in treating various types of hair loss, including androgenetic alopecia, alopecia areata, frontal fibrosing alopecia, and hair transplant technologies, but reports no new clinical results.
20 citations
,
August 2019 in “Expert Opinion on Drug Safety” This review examines the cognitive effects of medications for lower urinary tract symptoms and indicates that muscarinic antagonists, particularly oral oxybutynin, pose the highest risk for cognitive impairment.
14 citations
,
May 2021 in “Marine Drugs” This review discusses the therapeutic properties of polydeoxyribonucleotides derived from marine organisms for wound healing and inflammation, but it reports no new clinical results.
14 citations
,
July 2010 in “British Journal of Dermatology” This report discusses the possibility that estrogens might play a greater role than androgens in female pattern hair loss, without presenting new research findings.
11 citations
,
March 2020 in “American Journal of Medical Genetics Part A” This study identified a novel homozygous EDNRA variant linked to Oro-Oto-Cardiac Syndrome and showed that EDNRA signaling is essential for normal craniofacial and cardiovascular development.
11 citations
,
August 1997 in “Expert Opinion on Therapeutic Patents” This review discusses nearly 70 patent applications for the treatment of androgenetic alopecia and other hair conditions, highlighting the mechanisms of action explored but reports no clinical results.
10 citations
,
June 2021 in “Primates” This study found that wild geladas in Ethiopian crop areas experienced higher levels of human disturbance and health issues, such as increased parasitic infections, compared to those in pasture areas.
9 citations
,
March 2024 in “Journal of Biomaterials Applications” This study developed dissolving microneedles using specific polymers for transdermal delivery of rizatriptan benzoate, demonstrating improved drug skin penetration and significant alleviation of migraine symptoms in vivo compared to passive diffusion, suggesting potential advantages over conventional treatment methods for acute migraine.
9 citations
,
July 2020 in “Experimental Dermatology” This review emphasizes the potential of repurposing topical L-thyroxine for skin ulcers and telogen effluvium and highlights the need for further exploration of its use in dermatology.
4 citations
,
September 2024 in “BMC Cancer” In this prospective phase II clinical trial, researchers are investigating whether adding dutasteride to combined androgen blockade can improve the response rate and clinical outcomes for patients with androgen receptor-positive recurrent or metastatic salivary duct carcinoma.
2 citations
,
January 2012 in “InTech eBooks” This chapter provides an overview of chemotherapy-induced alopecia, discussing its biological and clinical aspects, current experimental models and treatments, and calls for improved understanding to prevent and manage it.
1 citations
,
January 2014 in “Elsevier eBooks” This review discusses melanocytes' role in pigmentation, their clinical significance in conditions like vitiligo and hair graying, and highlights current research on hair follicle regeneration without reporting new clinical results.
1 citations
,
January 2009 in “Trepo - Institutional Repository of Tampere University” This study found that vitamin D regulates cholesterol metabolism and may influence prostate cancer development through mechanisms affecting prostate cell growth and sex hormone metabolism.
1 citations
,
October 2018 in “InTech eBooks” This article reviews treatment approaches for cicatricial alopecia, describing how medication efficacy varies and suggesting autologous hair transplantation for stable cases; no new clinical data are presented.
March 2026 in “Frontiers in Pharmacology” The study concluded that the Exprecell™ device for preparing anticoagulant-free f-PRF increases volume yield and simplifies the process while maintaining biological activity comparable to conventional methods, suggesting potential clinical utility.
February 2024 in “PloS one” This study found that certain nutraceuticals did not interfere with tamoxifen's inhibition of estrogen in breast cancer cells and may enhance its effects, suggesting potential as an adjuvant therapy for hair loss in patients undergoing endocrine therapy.
November 2020 in “Elsevier eBooks” This source outlines various antiandrogen and androgen inhibitor drugs used to treat cutaneous disorders of hyperandrogenism, detailing their mechanisms, uses, dosages, and side effects, with emphasis on spironolactone, finasteride, dutasteride, and oral contraceptives.
January 2016 in “Research Explorer (The University of Manchester)” Activating the Eda/Edar pathway improves wound healing by enhancing hair follicle growth.
February 2013 in “Journal of The American Academy of Dermatology” There is no significant link between insulin resistance and certain hair disorders like idiopathic hirsutism and androgenic alopecia.
February 2013 in “Journal of The American Academy of Dermatology” Hair loss is a common but often unreported side effect of cancer treatments, especially for breast and prostate cancers.