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Testosterone is linked to cardiovascular risk factors and stroke, but its exact role is unclear.

Low androgen levels might delay prostate cancer but could lead to more aggressive, therapy-resistant cancers.

Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.

Noggin gene inactivation causes skeletal defects in mice, varying by genetic background.

Fibroblast changes in systemic sclerosis may help understand disease severity and treatment.

Insulin resistance and high male hormone levels are major causes of Polycystic Ovary Syndrome.

Krt15+ cells in the mouse intestine resist radiation and can start tumors.

Targeting Vδ1+T-cells may help treat alopecia areata.

Thiazole, a sulfur and nitrogen chemical, is useful in creating potential drugs for conditions like seizures, cancer, bacterial infections, tuberculosis, inflammation, malaria, viruses, Alzheimer's, diabetes, and A1-receptor issues.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

Some drugs may help treat both COVID-19 and radiation injury.

Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.

Activating Nrf2 can help protect against hearing loss.

Certain diets may help with hair growth in people with different types of hair loss.

New treatments like nanotechnology show promise in improving skin cancer therapy.

Follistatin and LIN28B together improve the ability of inner ear cells in mice to regenerate into hearing cells.

Hormone therapy increases the risk of heart-related issues in transgender women and may affect heart health in transgender men.

The document concludes that a systematic approach is crucial to identify causes of androgen excess in women beyond the most common cause, Polycystic ovary syndrome (PCOS).

Removing certain brain receptors in mice worsens seizure severity and response to treatment during hormone withdrawal.

Current methods can't fully recreate skin and its features, and more research is needed for clinical use.

Leptin-deficient mice, used as a model for Type 2 Diabetes, have delayed wound healing due to impaired contraction and other dysfunctional cellular responses.

More high-quality research is needed to recommend flavonoids and saponins for clinical use.

Pediatric endocrinologists should provide early fertility counseling and preservation options to young patients at risk of infertility.

A special receptor in sensory nerve endings helps control how they respond to stretching.

Using three different drugs together may better treat eye diseases like glaucoma and macular degeneration.

Cyclosporine-A can cause serious blood clots in the brain, so patients need careful monitoring.

Retinoids are effective for various skin conditions and hair loss but have serious side effects, so low doses are recommended.

Hair loss can cause stress and mental health issues, so treatments should address both the physical and psychological aspects, involving a team of dermatologists, psychologists, and hair specialists.

Retinoic acid affects male and female muscle energy use and function differently.

Re-evaluating minoxidil, reducing sodium intake, and addressing arteriolar hypertrophy can improve hypertension management.