Gut–Ovary Axis and Multiomic Insights into PCOS in a DHEA-Induced Rat Model

    December 2025 in “ Scientific Reports ”
    Zhi Chen, Qiongqiong Lu, Aolei Lin … Ming Xia
    Studysummary In this study, researchers observed that DHEA-induced PCOS rats experienced significant changes in gut microbiota and metabolic profiles, particularly affecting steroid and lipid metabolism, suggesting the gut-ovary axis may play a role in the pathogenesis of PCOS.
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    Research cited in this study 4

    1. Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee The Journal of Clinical Endocrinology and Metabolism · 2019
    2. Consensus on Women's Health Aspects of Polycystic Ovary Syndrome: The Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group Fertility and sterility · 2011
    3. Polycystic Ovary Syndrome: Etiology, Pathogenesis, and Diagnosis Nature Reviews Endocrinology · 2011
    4. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome Fertility and Sterility · 2004