Altered Hormone and Bioactive Lipid Plasma Profile in Rodent Models of Polycystic Ovarian Syndrome Revealed by Targeted Mass Spectrometry

    October 2024 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Hannah C. Scott, Martin Philpott, G. Berridge … Benedikt M. Kessler

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study examined lipid changes in rat models of polycystic ovarian syndrome, finding that letrozole and dihydrotestosterone treatments led to some lipid alterations similar to human PCOS, while other changes were unique to the models.
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    Research cited in this study 4

    1. Androgen Excess: Investigations and Management Best Practice & Research in Clinical Obstetrics & Gynaecology · 2016
    2. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS) Human Reproduction · 2003
    3. Prevalence of Polycystic Ovaries in Women with Androgenic Alopecia European journal of endocrinology · 2003
    4. Bioavailability of Albumin-Bound Testosterone The Journal of Clinical Endocrinology & Metabolism · 1985