Altered Hormone and Bioactive Lipid Plasma Profile in Rodent Models of Polycystic Ovarian Syndrome Revealed by Targeted Mass Spectrometry

October 2024 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Hannah C. Scott, Martin Philpott, G. Berridge, Zhanru Yu, Darragh P. O’Brien, Christian Becker, Cecilia Lindgren, Udo Opperman, Joerg Mueller, Martin Fritsch, Adán Pinto-Fernández, Benedikt M. Kessler

polycystic ovarian syndrome PCOS letrozole 5α-androstene-3,17-dione testosterone dihydrotestosterone dehydroepiandrosterone-sulphate allopregnanolone progesterone pregnenolone D-sphingosine 25-hydroxycholesterol leukotriene C4 4-cholesten-3-one DHT DHEA-S

TLDR Rodent models of PCOS show some similar and some different lipid changes compared to humans.

The study investigates the plasma lipid profiles in rodent models of polycystic ovarian syndrome (PCOS) using a targeted mass spectrometry-based lipidomics workflow. The research found that letrozole treatment in rats significantly increased levels of 5α-androstene-3,17-dione and testosterone, while dihydrotestosterone treatment increased dehydroepiandrosterone-sulphate and allopregnanolone but decreased testosterone, progesterone, pregnenolone, and D-sphingosine. Both models showed reduced levels of 25-hydroxycholesterol and leukotriene C4, and increased 4-cholesten-3-one, which are not typically altered in human PCOS. These findings suggest that while some lipid changes in these rodent models are similar to human PCOS, others are not, indicating the complexity of using these models for PCOS research.

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