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This study found that while rat models treated with letrozole and dihydrotestosterone exhibit altered sterol, leukotriene, and steroid hormone profiles similar to human PCOS, significant differences remain.

This study examined lipid changes in rat models of polycystic ovarian syndrome, finding that letrozole and dihydrotestosterone treatments led to some lipid alterations similar to human PCOS, while other changes were unique to the models.

In this study, 4-substituted N-(1,1-dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides were synthesized and evaluated in vitro as potential 5 alpha-reductase inhibitors and antiandrogens.

This study found that SZ95 sebocytes and HaCaT keratinocytes exhibit distinct enzyme expressions and activities, implicating their different roles in androgen metabolism and homeostasis in vitro.

This article reviews recent advances in the synthesis of oxasteroids and reports no new experimental results.