research Therapy for Alopecia Areata in Mice by Stimulating the Hair Cycle with Parathyroid Hormone Agonists Linked to a Collagen-Binding Domain
PTH-CBD helps reduce hair loss in mice by stimulating hair growth directly.
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780-810 / 1000+ resultsresearch Psoriasis in the limelight: the remarkable career of an old skin disease
In this study, tofacitinib was found to be a promising treatment for adolescents with alopecia areata, showing significant hair regrowth in most patients with mild adverse effects, despite limitations like small sample size and lack of control group.
research Pathology in Practice
A 7-year-old dog with a rare autoimmune disease was euthanized due to severe anemia and poor prognosis.
research Position of systemic therapy in the treatment of lichen pigmentosus
This study suggests that combining tranexamic acid with low-dose oral retinoids may offer moderate to good improvements for lichen plan pigmentosus, although larger trials are needed for confirmation.
research Lupus Panniculitis of the Scalp Presenting as a Patchy Nonscarring Alopecia: Report of an Uncommon Case
In this report, a unique case of lupus panniculitis of the scalp was diagnosed in a 40-year-old woman presenting with non-scarring patchy alopecia, which responded completely to oral prednisolone and methotrexate treatment.
research Papillon-Lefévre Syndrome: A Rare Case Report and a Brief Review of Literature
This case study highlights the unique occurrence of Papillon-Lefévre syndrome in two siblings from a consanguineous family, emphasizing the potential role of genetic factors in the disease's development.
research Forensic DNA phenotyping: a review on SNP panels, genotyping techniques, and prediction models
This review found that current forensic DNA phenotyping panels for biogeographical ancestry and visible traits face significant limitations due to inconsistencies in terminology, genetic understanding, and genotyping technologies, highlighting the need for harmonization and further research.
research De novo mutations in monilethrix
In this study, researchers identified two de novo germline missense mutations in the hair keratins hHb1 and hHb6 in patients with monilethrix whose parents were not clinically affected.
research Atrichia with papular lesions
This report discusses the accurate diagnosis of atrichia with papular lesions, emphasizing its distinction from alopecia universalis to prevent unnecessary steroid treatment, and presents a case matching APL diagnostic criteria.
research Clinical Features and Current Therapeutic Approaches to Monilethrix: A Systematic Review
This systematic review identified topical and oral minoxidil as the most effective treatments for monilethrix, but noted the varying efficacy of oral retinoids and other treatments.
research Identification of Trichophyton rubrum by Nested PCR Analysis from Paraffin Embedded Specimen in Trichophytia Profunda Acuta of the Glabrous Skin
This case study identified Trichophyton rubrum as the cause of trichophytia profunda acuta in a patient using nested PCR, suggesting an alternative diagnostic approach when KOH tests and cultures fail.
research A case of MBTPS1‐related disorder due to compound heterozygous variants in MBTPS1 gene: Genotype–phenotype expansion and the emergence of a novel syndrome
In this study, researchers identified compound heterozygous variants in the MBTPS1 gene associated with ectodermal dysplasia features in a 14-year-old female, broadening the known disorder spectrum linked to these genetic mutations.
research Autosomal dominant monilethrix with incomplete penetrance due to a novel KRT86 mutation in a Chinese family
research Doxetaxel: new indication. Prostate cancer: a few more weeks.
In this study, docetaxel combined with prednisone significantly extended survival by about 2.5 months in men with hormone-resistant metastatic prostate cancer compared to mitoxantrone plus prednisone, despite the potential for severe adverse effects.
research Biologic: A Double Edged Sword - A Case of Etanercept Induced Alopecia Areata in a Patient with Psoriasis Vulgaris
This review outlines the changing landscape of psoriasis vulgaris treatment with biologics, which offer benefits but also have increasingly recognized adverse effects, without presenting new clinical results.
research The Therapeutic Effect and In Vivo Assessment of Palmitoyl- GDPH on the Wound Healing Process
In this study, the novel fatty acid-conjugated tetrapeptide Palmitoyl-GDPH enhanced wound healing in rats by improving re-epithelialization and collagen deposition with minimal toxicity observed at the used dosage.
research A synbiotic preparation (SIM01) for post-acute COVID-19 syndrome in Hong Kong (RECOVERY): a randomised, double-blind, placebo-controlled trial
This study found that treatment with the synbiotic SIM01 significantly alleviated multiple symptoms of post-acute COVID-19 syndrome compared to placebo, suggesting potential management benefits through gut microbiome modulation.
research Application of Topical Immunotherapy in the Treatment of Alopecia Areata: A Review and Update
This review summarizes the pharmacology, mechanisms, and clinical efficacy of topical immunotherapy for alopecia areata but reports no new clinical results.
research Learning From Success and Failure: Biologics for Non-approved Skin Diseases
This review discusses the potential of biologics for treating various skin disorders, highlighting positive outcomes in conditions like pityriasis rubra pilaris and lupus, while noting mixed efficacy in others like alopecia areata; it reports no new clinical results.
research British Cosmetic Dermatology Group
Imiquimod improved skin pigmentation in most patients with xeroderma pigmentosum and may prevent further skin cancer, but some treatments can have side effects.
research Accelerative action of topical piperonylic acid on mice full thickness wound by modulating inflammation and collagen deposition
In this study, topical piperonylic acid was found to improve wound healing in mice by activating EGFR and modulating gene expression related to the healing process.
research NEW YORK ACADEMY OF MEDICINE, SECTION OF DERMATOLOGY AND SYPHILOLOGY
This abstract presents a case of arsenical dermatitis with pigmentation and alopecia developed during treatment with arsphenamine for a positive Wassermann reaction.
research Efficacy, safety and dose response of STS01, a topical controlled release nanoparticle formulation (dithranol/Prosilic), in adults with mild to moderate patchy alopecia areata: A randomised, double-blind, multicentre, phase 2 trial
In this phase 2 trial, STS01 1% significantly improved hair regrowth in patients with mild to moderate patchy alopecia areata compared to placebo, with a manageable skin irritation side effect profile.
research JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician
This systematic review details monitoring and safety guidelines for primary care physicians regarding Janus kinase and tyrosine kinase 2 inhibitors used in treating inflammatory skin conditions, emphasizing their efficacy and the importance of updated knowledge due to associated box warnings and increasing use.
research Suppression of mammary tumorigenesis in transgenic mice by the RXR-selective retinoid, LGD1069.
This study found that the retinoid LGD1069 suppressed mammary tumorigenesis in a mouse model without observable toxicity, while TTNPB showed modest effects but was associated with significant toxicity.
research Microarray Gene Expression Analysis of Lesional Skin in Canine Pemphigus Foliaceus
This study found that canine pemphigus foliaceus skin lesions exhibit a distinct immune signature, with upregulated pro-inflammatory and Th17-related genes, showing similarities to human pemphigus. Further research using advanced sequencing is needed to better understand the disease's pathogenesis.
research Identification of Pygopus 2 as a component of the ribosomal RNA transcription complex in cancer
This study found that the NHD domain, but not the PHD domain, of hPygo2 is crucial for Wnt-independent growth of ovarian cancer cells, and identified a key interaction with Treacle protein involved in ribosomal biogenesis.
research 1616 Cross-comparison of inflammatory skin disease transcriptomics identifies PTEN as a pathogenic disease classifier in cutaneous lupus erythematosus
This study found that tissue transcriptomics and a normalization approach can effectively cluster nine inflammatory skin diseases and identify specific biomarkers, including PTEN as a marker for cutaneous lupus erythematosus.
research Refractory Dermatophytosis in a Spitz Dog Successfully Managed with Posaconazole in India: A Case Report
In this study, a case of a Spitz dog with refractory dermatophytosis demonstrated marked clinical improvement and complete cure with Posaconazole, highlighting the potential of antifungal susceptibility testing to guide effective treatment in persistent infections unresponsive to standard therapies.
research Sarolaner, a novel parasiticide in the treatment of generalized demodicosis in dogs-a case study
In this case study, researchers found that treatment with sarolaner led to complete recovery from generalized demodicosis in six dogs within four weeks, resolving clinical signs without adverse reactions.