Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that introducing the recombinant rat OTC gene into SPF-ASH mice restored normal hair growth and metabolic function, improving symptoms associated with OTC deficiency.

This study found that introducing rat ornithine transcarbamylase gene into spf-ash mice improved liver and intestinal enzyme activity and normalized some metabolic indicators.

In this animal study, finasteride treatment altered testosterone metabolism in rat corpus cavernosum, linked to mechanisms of erectile dysfunction, but these changes were reversed after stopping the drug, suggesting post-treatment sexual side effects may relate more to central control dysfunction than peripheral issues.

This study on adult male rats found that finasteride treatment led to molecular changes linked to erectile dysfunction, while withdrawal from the drug did not alter these parameters.

In this study, introducing the rat OTC gene into spf-ash mice led to increased OTC activity and normalized hair growth and biochemical markers like urinary orotic acid and serum citrulline, partially correcting the symptoms of OTC deficiency.

A fatty acid/protein complex in human hair helps protect it from damage.

This study reports that hypomorphic alleles of the Ass1 gene in mice resemble human CTLN1, providing a potential model for preclinical studies and indicating that standard treatments for CTLN1 can rescue phenotypes.

This review classifies mutant mice with hair abnormalities into six categories, providing an annotated table that serves as a reference for understanding the molecular controls of hair growth.

This study found that vomiting was the most common side effect of sodium valproate in children under two with epilepsy.

This chapter reviews studies on the side effects of cytostatics and immunosuppressive drugs, detailing various toxicities such as cardiovascular, pulmonary, and neurotoxicity, but provides no new clinical results.

The conference presented findings on how vitamin D levels, genetic factors, and lifestyle choices like smoking and yoga affect various health conditions and diseases.

Cyclosporin and minoxidil promote hair growth.

This case study describes a 29-year-old woman whose severe liver injury was primarily attributed to chronic arsenic exposure, highlighting the importance of recognizing metal toxicity in patient care.

This review reports on the current state and potential of solid lipid nanoparticles for drug delivery, emphasizing their safety, biocompatibility, and ease of production, and highlights challenges in translating them to clinical practice, including active clinical trials.

This study found that the expressions of CDK inhibitors p21waf1/cip1 and p27kip1 were higher during the anagen phase compared to telogen, suggesting a role in follicular epithelial cell differentiation.

This review explores the potential of self-amplifying RNA technology for protein replacement therapy in various health disorders but reports no new experimental results, indicating challenges remain for clinical approval.

This study reviewed literature on pediatric acrodermatitis enteropathica and found that zinc deficiency occurred in 75.9% of cases, with zinc supplementation showing therapeutic efficacy in 91.4% of patients; however, it was often ineffective in those with underlying metabolic disorders.

This source does not report specific results but compiles information on recent advancements in Advanced Therapy Medicinal Products and regenerative medicine from non-academic sources as of March 2026.

This study suggests that post-finasteride syndrome and post-SSRI sexual dysfunction share potential etiopathogenetic mechanisms involving brain modulators, neurotransmitters, and gut microbiota, although more research is needed to understand these conditions fully.

This study observed that vomiting was the most frequent side effect of sodium valproate in children under two years old, with anemia, hair loss, and appetite loss being less common.

This article highlights the need to consider topical minoxidil as a differential diagnosis for unexplained headache and dizziness due to its potential side effects.

In this study, targeting ornithine decarboxylase overexpression to hair follicle keratinocytes in mice was sufficient to promote skin tumor development without additional tumor promoters.

This study found that overexpression of ornithine decarboxylase and activated Ha-ras together led to a high rate of tumor development in a mouse model without additional carcinogens.

This study found that overexpression of a mutated ornithine decarboxylase transgene in mice led to complete hair loss, which could be prevented or reversed with an ODC inhibitor.

This study found that overexpression of the enzyme ornithine decarboxylase in transgenic mice led to UVB-induced skin tumors, but this was prevented by the ODC inhibitor α-difluoromethylornithine.

In this study, overexpression of ornithine decarboxylase accelerated basal cell carcinoma in Ptch1+/– mice under UVB exposure, while its inhibition reduced tumor induction, suggesting potential chemoprevention strategies in humans.

This study found that inhibiting the enzyme ornithine decarboxylase (ODC) prevented UVB-induced basal cell carcinomas in a mouse model, suggesting ODC is a potential target for chemoprevention strategies.

This study suggests that polyamines regulate CK2 enzyme activity and its subcellular distribution, as demonstrated in mouse models and cell cultures with elevated levels of ornithine decarboxylase.