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Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Men's sensitivity to male hormones might affect how severe COVID-19 gets for them.

Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.

Human leukocytes and beard hair follicle cells have internal daily clocks, and PER1 and PER3 genes may indicate individual circadian rhythms.

Diabetes often causes various skin problems and complications.

Using systemic drugs as creams for skin conditions shows promise, but more research is needed to confirm their effectiveness and safety.

New method uses hair follicle cells to estimate human body clock phase, potentially improving sleep disorder diagnosis.

Scalp involvement in pemphigus means the disease is more severe and harder to treat.

No link found between Coxsackie viruses and pemphigus.

Pregnancy can cause skin changes and affect existing skin conditions, with limited treatment options due to the need for fetal safety.

Disrupting natural body clocks increases the risk of developing type 2 diabetes.

Finasteride may cause gum side effects in some patients.

A patient with "strawberry gingivitis" improved after correct treatment for Granulomatosis with polyangiitis, highlighting the need for early diagnosis.

Topical imiquimod is as effective as 5-fluorouracil for treating actinic keratosis, with about a 5% risk of it turning into squamous cell carcinoma.

Diabetes can cause a variety of skin disorders, some of which may signal more serious health issues.

Skin symptoms can indicate endocrine disorders and have various treatments.

Low-level Laser Therapy may help reduce inflammation, pain, and aid healing, but more research is needed to confirm its effectiveness and establish standard treatment guidelines.

Scientists found a new, less invasive way to study body clocks using hair cells, which shows shift workers' body clocks don't match their lifestyles.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

Skin has specialized touch receptors that can tell different sensations apart.

Shrinking skin cancer increases the chance of cancer in nearby lymph nodes.

Microneedle technology has improved drug delivery and patient comfort but needs more research for broader use.

Genetic screening is crucial for accurately diagnosing APS-1 due to its varied symptoms.

Immunosuppressive and anti-TNF therapies in IBD patients can increase the risk of skin cancer and cause various skin issues.

Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.

Avoiding certain nutrients and drugs may help manage pemphigus.

HIV can cause various severe or unusual skin conditions that help indicate the presence and stage of the disease.

Shift nurses show altered body temperature and stress hormone levels, suggesting their body clocks adjust to irregular schedules.

People with lichen planus have higher bad cholesterol and lower good cholesterol, increasing their risk for heart disease.

Fibroblasts, cells usually linked to tissue repair, also help regenerate various organs and their ability decreases with age. Turning adult fibroblasts back to a younger state could be a new treatment approach.