December 2022 in “Clinical and experimental dermatology and therapies” In this study, the addition of a topical gel containing growth-factor mimicking oligopeptides and other ingredients showed improved efficacy in subjects with androgenic alopecia using minoxidil or finasteride compared to drug treatment alone.
July 2022 in “http://isrctn.com/” Adding a cosmetic gel with caffeine, taurine, and growth factors to standard hair loss treatments could improve results.
14 citations
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October 2020 in “Natural Products and Bioprospecting” This review discusses current topical treatments, natural products, and complementary therapies for androgenetic alopecia, but it reports no new clinical results.
3 citations
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April 2019 in “Journal of Dermatological Treatment” This review discusses the use of phosphodiesterase inhibitors for alopecia, finding promising preliminary results with topical caffeine for androgenetic alopecia and telogen effluvium, but limited success in alopecia areata.
1 citations
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July 2023 in “Cureus” This article examines advancements in understanding and managing androgenic alopecia (male pattern baldness), discussing genetic and psychological factors, diagnostic methods, classifications, and various treatment options, including traditional and emerging therapies, to aid healthcare professionals in making informed treatment decisions.
2 citations
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July 2021 in “Dermatologic Therapy” This case study reports a 58-year-old woman experiencing pressure-induced alopecia with concomitant acute telogen effluvium after severe COVID-19, suggesting a potential link between prolonged hospitalization and hair loss.
1 citations
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February 2025 in “Supportive Care in Cancer” Safe treatments like minoxidil and spironolactone can help manage hair loss in breast cancer patients without increasing cancer risk.
September 2022 in “Polish Hyperbaric Research” This study analyzed 57 medicinal and cosmetic preparations available in Poland for treating alopecia, finding that finasteride is the most common active ingredient, with many products being in tablet or shampoo form and categorized as prescription drugs and cosmetics.
This abstract introduces TrichoFoam™, a new foaming vehicle for compounding pharmacies, designed to be a gentle, non-irritating option for alopecia treatment, acknowledging that current topical treatments are limited and oral products may cause adverse effects.
This case report discusses a patient with female androgenetic alopecia and chronic telogen effluvium, emphasizing the importance of follicular unclogging to enhance treatment effectiveness, combining deep cleaning, caffeine application, physical stimulation, and lifestyle changes as an individualized, effective alternative to oral medications.
September 2023 in “Authorea (Authorea)” In this case report, a 35-year-old man with androgenetic alopecia showed significant improvement in hair thickness and density after six months of conservative therapy with topical minoxidil, oral finasteride, and a gel with oligopeptides, caffeine, and taurine.
April 2024 in “Acta scientific dental sciences” This case study describes a 45-year-old male with black hairy tongue who experienced complete resolution of tongue discoloration and improved halitosis after receiving treatment focused on enhanced oral hygiene, tongue brushing, and smoking cessation.
1 citations
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March 2018 in “Dermatologie pro praxi” This article reviews over-the-counter products and active ingredients marketed for hair loss treatment, noting that many lack robust efficacy evidence except for minoxidil, which has temporary effects, and highlights the caution needed when recommending products to pregnant and breastfeeding women.
December 2022 in “Zenodo (CERN European Organization for Nuclear Research)” This review discusses the potential benefits of using topical caffeine products for treating androgenic alopecia but reports no new clinical findings; the authors highlight caffeine's possible positive effects based on existing studies.
2 citations
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January 2022 in “Dermatologic Therapy” Natural products like saw palmetto, caffeine, melatonin, marine extracts, rosemary oil, procyanidin, pumpkin seed oil, and cannabidiol oil could potentially treat male hair loss.
August 2024 in “Quality in Sport” This review article examines the latest understanding of androgenetic alopecia's causes and treatment options, emphasizing current research on alternative treatments beyond the approved medications, finasteride and minoxidil, due to potential side effects and the psychological impact of the condition.
52 citations
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June 1981 in “International Journal of Dermatology” Oral retinoids are effective for severe skin conditions but require careful use due to side effects.
34 citations
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November 1987 in “Archives of Dermatology” This study found that oral minoxidil showed limited cosmetic effectiveness in treating severe alopecia areata, with only 18% of patients experiencing a noticeable response.
21 citations
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March 2021 This study reviewed the literature on low-dose oral minoxidil as a primary treatment for various hair loss disorders, concluding that it is a successful and well-tolerated alternative to topical minoxidil for patients with poor adherence to other therapies.
19 citations
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June 2020 in “International Journal of Dermatology” In this systematic review, oral minoxidil was found to be a safe and effective treatment for androgenetic alopecia and alopecia areata, with additional benefits for female pattern hair loss and other types of alopecia, although common side effects included hypertrichosis and postural hypotension.
11 citations
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July 2012 in “International Journal of Trichology” Caffeine may help hair growth in hereditary hair loss.
10 citations
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October 2009 in “Clinical Therapeutics” This study found that the orally disintegrating tablet and standard tablet formulations of finasteride met bioequivalence criteria in fasting healthy adult male Han Chinese volunteers, although there was a significant difference in time to maximum concentration.
January 2025 in “Acta Dermatovenerologica Alpina Pannonica et Adriatica” In this study, oral minoxidil treatment significantly increased serum VEGF levels and improved hair growth measures compared to a control group, suggesting its potential as an effective approach for promoting hair regrowth in androgenetic alopecia.
8 citations
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January 2020 in “Skin Pharmacology and Physiology” This article discusses the potential for topical caffeine as a natural alternative for treating androgenetic alopecia due to its ability to penetrate skin, but it reports no new clinical findings.
153 citations
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October 2012 in “Skin Pharmacology and Physiology” This review discusses the use of caffeine in cosmetics for its fat-reducing, antioxidant, and hair growth properties, but reports no new research findings.
35 citations
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June 2017 in “Pharmaceutical research” This study presented a new two-dimensional model that successfully predicts transdermal permeation of caffeine, highlighting the significant role of the follicular pathway in increasing systemic bioavailability.
32 citations
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December 2017 in “Journal of Drug Delivery Science and Technology” This study found that co-delivery of minoxidil and caffeine in transfersomes with an optimized polysorbate formulation enhanced hair length and weight in vivo.
12 citations
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December 2023 in “Journal of Applied Pharmaceutical Sciences and Research” In this research, caffeine's versatile pharmacological actions were highlighted, demonstrating its stimulant, bronchodilator, diuretic, and potential anticancer effects through interactions with adenosine receptors, phosphodiesterase, and renal tubules, revealing valuable insights for drug development and therapeutic applications in medicine.
7 citations
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October 2024 in “AAPS PharmSciTech” This study developed a caffeine-loaded solid lipid nanoparticle gel, observing significant reduction in subcutaneous fat tissue thickness in histological tests compared to an untreated group, suggesting it could effectively treat cellulite as a promising nanocosmeceutical gel.
This review discusses caffeine's potential role in treating androgenetic alopecia by counteracting DHT effects on hair follicles and enhancing cell proliferation, but reports no new clinical results.